Young K Chen
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Explore the profile of Young K Chen including associated specialties, affiliations and a list of published articles.
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10
Citations
157
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Recent Articles
1.
Chen Y, Kanouni T, Arnold L, Cox J, Gardiner E, Grandinetti K, et al.
J Med Chem
. 2024 Jan;
67(3):1747-1757.
PMID: 38230963
RAF, a core signaling component of the MAPK kinase cascade, is often mutated in various cancers, including melanoma, lung, and colorectal cancers. The approved inhibitors were focused on targeting the...
2.
Chandhasin C, Dang V, Perabo F, Del Rosario J, Chen Y, Filvaroff E, et al.
Anticancer Drugs
. 2023 Apr;
34(10):1122-1131.
PMID: 37067993
Histone lysine demethylase 4 (KDM4) is an epigenetic regulator that facilitates the transition between transcriptionally silent and active chromatin states by catalyzing the removal of methyl groups on histones H3K9,...
3.
Kanouni T, Severin C, Cho R, Yuen N, Xu J, Shi L, et al.
J Med Chem
. 2020 Oct;
63(23):14522-14529.
PMID: 33034194
Histone demethylase LSDl (KDMlA) belongs to the flavin adenine dinucleotide (FAD) dependent family of monoamine oxidases and is vital in regulation of mammalian biology. Dysregulation and overexpression of LSD1 are...
4.
Nie Z, Shi L, Lai C, Severin C, Xu J, Del Rosario J, et al.
Bioorg Med Chem Lett
. 2018 Nov;
29(1):103-106.
PMID: 30409536
The histone demethylase LSD1 is a key enzyme in the epigenetic regulation of gene transcription. Here we present our efforts to discover small molecule reversible inhibitors of LSD1 as an...
5.
Chen Y, Bonaldi T, Cuomo A, Del Rosario J, Hosfield D, Kanouni T, et al.
ACS Med Chem Lett
. 2017 Aug;
8(8):869-874.
PMID: 28835804
Histone lysine demethylases (KDMs) play a vital role in the regulation of chromatin-related processes. Herein, we describe our discovery of a series of potent KDM4 inhibitors that are both cell...
6.
Kerrigan M, Jeon S, Chen Y, Salvi L, Carroll P, Walsh P
J Am Chem Soc
. 2009 May;
131(24):8434-45.
PMID: 19476375
(Z)-trisubstituted allylic alcohols are widespread structural motifs in natural products and biologically active compounds but are difficult to directly prepare. Introduced herein is a general one-pot multicomponent coupling method for...
7.
Chen Y, Yoshida M, MacMillan D
J Am Chem Soc
. 2006 Jul;
128(29):9328-9.
PMID: 16848457
The first enantioselective organocatalytic amine conjugate addition has been successfully developed. The application of LUMO-lowering iminium catalysis has enabled the highly chemo- and enantioselective 1,4-addition of a rationally designed N-silyloxycarbamate...
8.
Jeon S, Chen Y, Walsh P
Org Lett
. 2005 Apr;
7(9):1729-32.
PMID: 15844892
[reaction: see text] Hydroboration of ethoxy acetylene, transmetalation to zinc, and addition to aldehydes in the presence of a chiral amino alcohol ligand (MIB) affords hydroxy enol ethers with high...
9.
Chen Y, Walsh P
J Am Chem Soc
. 2004 Mar;
126(12):3702-3.
PMID: 15038709
In this Communication, we outline a new one-pot, multicomponent coupling reaction that allows easy access to (Z)-trisubstituted allylic alcohols. Our strategy is based on E to Z isomerization of the...
10.
Chen Y, Lurain A, Walsh P
J Am Chem Soc
. 2002 Oct;
124(41):12225-31.
PMID: 12371863
Catalytic and enantioselective synthesis of amino acids is a subject of intense interest in the field of asymmetric catalysis. Traditionally, researchers have concentrated their efforts largely on the design and...