Young G Shin
Overview
Explore the profile of Young G Shin including associated specialties, affiliations and a list of published articles.
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Articles
44
Citations
263
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Recent Articles
1.
Park S, Lim J, Lee J, Lee J, Hwang S, Kim H, et al.
Xenobiotica
. 2023 Nov;
54(8):563-573.
PMID: 37971300
Polyethylene glycol (PEG) was introduced into synthetic bilirubin 3α and a PEGylated bilirubin 3α nanoparticle (BX-001N, Brixelle®) was developed for the first time.An microsomal stability study, in vivo PK studies...
2.
Lim J, Park M, Park Y, Park S, Lee J, Hwang S, et al.
Molecules
. 2023 Apr;
28(7).
PMID: 37049985
There have been many attempts in pharmaceutical industries and academia to improve the pharmacokinetic characteristics of anti-tumor small-molecule drugs by conjugating them with large molecules, such as monoclonal antibodies, called...
3.
Lee J, Lee B, Choi J, Park Y, Park S, Park M, et al.
Molecules
. 2022 Dec;
27(23).
PMID: 36500706
The purpose of this study is to investigate the difference of in vitro-in vivo correlation of α-amanitin from clearance perspectives as well as to explore the possibility of extra-hepatic metabolism...
4.
Janku F, Beom S, Moon Y, Kim T, Shin Y, Yim D, et al.
Invest New Drugs
. 2022 Jul;
40(5):1001-1010.
PMID: 35802288
Preclinical models suggest anticancer activity of IM156, a novel biguanide mitochondrial protein complex 1 inhibitor of oxidative phosphorylation (OXPHOS). This first-in-human dose-escalation study enrolled patients with refractory advanced solid tumors...
5.
Park M, Lee B, Choi J, Park Y, Park S, Lim J, et al.
Molecules
. 2022 Mar;
27(6).
PMID: 35335372
Daporinad (FK866) is one of the highly specific inhibitors of nicotinamide phosphoribosyl transferase (NAMPT) and known to have its unique mechanism of action that induces the tumor cell apoptosis. In...
6.
Choi J, Park M, Shin S, Byeon J, Lee B, Park Y, et al.
Molecules
. 2021 Mar;
26(4).
PMID: 33671835
Sulfasalazine (SAS), an anti-inflammatory drug with potent cysteine/glutamate antiporter system xc-(SXC) inhibition has recently shown beneficial effects in brain-related diseases. Despite many reports related to central nervous system (CNS) effect...
7.
Lee B, Park S, Park Y, Shin S, Choi J, Park M, et al.
Pharmaceutics
. 2021 Jan;
13(1).
PMID: 33478046
Antibody-drug conjugate (ADC) linkers play an important role in determining the safety and efficacy of ADC. The Ortho Hydroxy-Protected Aryl Sulfate (OHPAS) linker is a newly developed linker in the...
8.
Lee B, Lim J, Park M, Shin S, Byeon J, Choi J, et al.
Transl Clin Pharmacol
. 2020 Oct;
28(3):147-159.
PMID: 33062628
Carisbamate is an antiepileptic drug and it also has broad neuroprotective activity and anticonvulsant reaction. In this study, a liquid chromatography-quadrupole time-of-flight mass spectrometric (LC-qTOF-MS) method was developed and applied...
9.
Shin S, Park Y, Park M, Byeon J, Lee B, Choi J, et al.
Life (Basel)
. 2020 Jul;
10(7).
PMID: 32707673
Neuro-inflammation is known to be one of the pathogenesis for the degenerative central nervous system (CNS) disease. Recently various approaches for the treatment of brain diseases by controlling neuro-inflammation in...
10.
Park Y, Park M, Byeon J, Shin S, Lee B, Choi J, et al.
Molecules
. 2020 May;
25(9).
PMID: 32397307
5-Amino-7-(2-phenylethyl)-2-(2-furyl)-pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c) pyrimidine (SCH 58261) is one of the new chemical entities that has been developed as an adenosine A receptor antagonist. Although SCH 58261 has been reported to be beneficial,...