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Young Ah Seo

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Articles 29
Citations 651
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Recent Articles
21.
Hennigar S, Seo Y, Sharma S, Soybel D, Kelleher S
Sci Rep . 2015 Jan; 5:8033. PMID: 25620235
Mammary gland involution is the most dramatic example of physiological cell death. It occurs through an initial phase of lysosomal-mediated cell death (LCD) followed by mitochondrial-mediated apoptosis. Zinc (Zn) activates...
22.
Seo Y, Lee S, Hennigar S, Kelleher S
J Biol Chem . 2014 Jul; 289(34):23653-61. PMID: 25016022
The zinc transporter ZnT2 imports zinc into secretory vesicles and regulates zinc export from the mammary epithelial cell. Mutations in ZnT2 substantially impair zinc secretion into milk. The lactogenic hormone...
23.
Seo Y, Li Y, Wessling-Resnick M
Neurotoxicology . 2013 Jun; 38:67-73. PMID: 23764342
Iron deficiency is a risk factor for manganese (Mn) accumulation. Excess Mn promotes neurotoxicity but the mechanisms involved and whether iron depletion might affect these pathways is unknown. To study...
24.
Lasry I, Seo Y, Ityel H, Shalva N, Pode-Shakked B, Glaser F, et al.
J Biol Chem . 2012 Jun; 287(35):29348-61. PMID: 22733820
Zinc is an essential mineral, and infants are particularly vulnerable to zinc deficiency as they require large amounts of zinc for their normal growth and development. We have recently described...
25.
Dempsey C, McCormick N, Croxford T, Seo Y, Grider A, Kelleher S
J Nutr . 2012 Feb; 142(4):655-60. PMID: 22357740
Dietary analysis predicts that marginal Zn deficiency is common in women of reproductive age. The lack of reliable biomarkers limits the capacity to assess Zn status and consequently understand effects...
26.
Seo Y, Lopez V, Kelleher S
Am J Physiol Cell Physiol . 2011 Feb; 300(6):C1479-89. PMID: 21289295
Female reproductive tissues such as mammary glands, ovaries, uterus, and placenta are phenotypically dynamic, requiring tight integration of bioenergetic and apoptotic mechanisms. Mitochondrial zinc (Zn) pools have emerged as a...
27.
Seo Y, Kelleher S
Physiol Genomics . 2010 Sep; 42A(4):219-27. PMID: 20858712
Zinc transporter 2 (ZnT2) plays a major role in zinc (Zn) export from the mammary gland. Recently, we determined that ZnT2 is associated with secretory vesicles reflecting its role in...
28.
Qian L, Lopez V, Seo Y, Kelleher S
Am J Physiol Cell Physiol . 2009 Jun; 297(2):C369-77. PMID: 19494234
The zinc transporter ZnT2 (SLC30A2) plays an important role in zinc secretion into milk during lactation. The physiological process of mammary gland secretion is regulated through complex integration of multiple...
29.
Kelleher S, Seo Y, Lopez V
Genes Nutr . 2009 Apr; 4(2):83-94. PMID: 19340474
Zinc (Zn) is required for numerous metabolic processes serving both a structural and catalytic role. The mammary gland has a unique Zn requirement resulting from the need to also transfer...