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Young Ah Seo

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Articles 29
Citations 651
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Recent Articles
11.
Vallianatos C, Raines B, Porter R, Bonefas K, Wu M, Garay P, et al.
Commun Biol . 2020 Jun; 3(1):331. PMID: 32572144
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
12.
Vallianatos C, Raines B, Porter R, Bonefas K, Wu M, Garay P, et al.
Commun Biol . 2020 Jun; 3(1):278. PMID: 32483278
Histone H3 lysine 4 methylation (H3K4me) is extensively regulated by numerous writer and eraser enzymes in mammals. Nine H3K4me enzymes are associated with neurodevelopmental disorders to date, indicating their important...
13.
Choi E, Aring L, Das N, Solanki S, Inohara N, Iwase S, et al.
FASEB J . 2020 Jan; 34(2):2929-2943. PMID: 31908045
Diet plays a significant role in the pathogenesis of inflammatory bowel disease (IBD). A recent epidemiological study has shown an inverse relationship between nutritional manganese (Mn) status and IBD patients....
14.
Choi E, Nguyen T, Iwase S, Seo Y
FASEB J . 2018 Sep; 33(2):2228-2240. PMID: 30247984
Hemochromatosis is a frequent genetic disorder, characterized by the accumulation of excess iron across tissues. Mutations in the FPN1 gene, encoding a cell surface iron exporter [ferroportin (Fpn)], are responsible...
15.
Choi E, Nguyen T, Gupta N, Iwase S, Seo Y
Sci Rep . 2018 Feb; 8(1):3163. PMID: 29453449
SLC39A8 encodes ZIP8, a divalent metal ion transporter. Mutations in the SLC39A8 gene are associated with congenital disorder of glycosylation type II and Leigh syndrome. Notably, affected patients with both...
16.
Grillo A, SantaMaria A, Kafina M, Cioffi A, Huston N, Han M, et al.
Science . 2017 May; 356(6338):608-616. PMID: 28495746
Multiple human diseases ensue from a hereditary or acquired deficiency of iron-transporting protein function that diminishes transmembrane iron flux in distinct sites and directions. Because other iron-transport proteins remain active,...
17.
Seo Y, Kumara R, Wetli H, Wessling-Resnick M
Biochem J . 2016 Sep; 473(22):4243-4254. PMID: 27681840
Divalent metal transporter-1 (DMT1) mediates dietary iron uptake across the intestinal mucosa and facilitates peripheral delivery of iron released by transferrin in the endosome. Here, we report that classical cannabinoids...
18.
Patchen B, Koppe T, Cheng A, Seo Y, Wessling-Resnick M, Fraenkel P
Blood Cells Mol Dis . 2016 Aug; 60:36-43. PMID: 27519943
Hepcidin, a peptide produced in the liver, decreases intestinal iron absorption and macrophage iron release by causing degradation of the iron exporter, ferroportin. Because its levels are inappropriately low in...
19.
Seo Y, Elkhader J, Wessling-Resnick M
Biometals . 2015 Dec; 29(1):147-55. PMID: 26693922
Flatiron (ffe) mice display features of "ferroportin disease" or Type IV hereditary hemochromatosis. While it is known that both Fe and Mn metabolism are impaired in flatiron mice, the effects...
20.
Seo Y, Wessling-Resnick M
FASEB J . 2015 Mar; 29(7):2726-33. PMID: 25782988
We examined the physiologic role of ferroportin (Fpn) in manganese (Mn) export using flatiron (ffe/+) mice, a genetic model of Fpn deficiency. Blood (0.0123 vs. 0.0107 mg/kg; P = 0.0003),...