Yosif M Ganat
Overview
Explore the profile of Yosif M Ganat including associated specialties, affiliations and a list of published articles.
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9
Citations
2353
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Recent Articles
1.
Fiore N, Ganat Y, Devkota K, Batorsky R, Lei M, Lee K, et al.
Cell Mol Life Sci
. 2022 Jan;
79(2):78.
PMID: 35044538
Three-dimensional (3D) in vitro culture systems using human induced pluripotent stem cells (hiPSCs) are useful tools to model neurodegenerative disease biology in physiologically relevant microenvironments. Though many successful biomaterials-based 3D...
2.
Oricchio E, Papapetrou E, Lafaille F, Ganat Y, Kriks S, Ortega-Molina A, et al.
Cell Rep
. 2014 Sep;
8(6):1677-1685.
PMID: 25242333
The long-term risk of malignancy associated with stem cell therapies is a significant concern in the clinical application of this exciting technology. We report a cancer-selective strategy to enhance the...
3.
Miller J, Ganat Y, Kishinevsky S, Bowman R, Liu B, Tu E, et al.
Cell Stem Cell
. 2013 Dec;
13(6):691-705.
PMID: 24315443
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) resets their identity back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset disorders. In this study,...
4.
Maroof A, Keros S, Tyson J, Ying S, Ganat Y, Merkle F, et al.
Cell Stem Cell
. 2013 May;
12(5):559-72.
PMID: 23642365
Human pluripotent stem cells are a powerful tool for modeling brain development and disease. The human cortex is composed of two major neuronal populations: projection neurons and local interneurons. Cortical...
5.
Ganat Y, Calder E, Kriks S, Nelander J, Tu E, Jia F, et al.
J Clin Invest
. 2012 Jul;
122(8):2928-39.
PMID: 22751106
Embryonic stem cells (ESCs) represent a promising source of midbrain dopaminergic (DA) neurons for applications in Parkinson disease. However, ESC-based transplantation paradigms carry a risk of introducing inappropriate or tumorigenic...
6.
Kriks S, Shim J, Piao J, Ganat Y, Wakeman D, Xie Z, et al.
Nature
. 2011 Nov;
480(7378):547-51.
PMID: 22056989
Human pluripotent stem cells (PSCs) are a promising source of cells for applications in regenerative medicine. Directed differentiation of PSCs into specialized cells such as spinal motoneurons or midbrain dopamine...
7.
Lee G, Papapetrou E, Kim H, Chambers S, Tomishima M, Fasano C, et al.
Nature
. 2009 Aug;
461(7262):402-6.
PMID: 19693009
The isolation of human induced pluripotent stem cells (iPSCs) offers a new strategy for modelling human disease. Recent studies have reported the derivation and differentiation of disease-specific human iPSCs. However,...
8.
Silbereis J, Cheng E, Ganat Y, Ment L, Vaccarino F
Stem Cells
. 2009 May;
27(5):1152-63.
PMID: 19418461
Neural stem or progenitor cells (NSC/NPCs) able to generate the different neuron and glial cell types of the cerebellum have been isolated in vitro, but their identity and location in...
9.
Ganat Y, Silbereis J, Cave C, Ngu H, Anderson G, Ohkubo Y, et al.
J Neurosci
. 2006 Aug;
26(33):8609-21.
PMID: 16914687
To identify the fates that astroglial cells can attain in the postnatal brain, we generated mice carrying an inducible Cre recombinase (Cre-ER(T2)) controlled by the human GFAP promoter (hGFAP). In...