John Silbereis
Overview
Explore the profile of John Silbereis including associated specialties, affiliations and a list of published articles.
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15
Citations
799
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0
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Recent Articles
1.
Kaur N, Kovner R, Gulden F, Pletikos M, Andrijevic D, Zhu T, et al.
Nature
. 2025 Jan;
638(8050):469-478.
PMID: 39814878
The ventrolateral pallial (VLp) excitatory neurons in the claustro-amygdalar complex and piriform cortex (PIR; which forms part of the palaeocortex) form reciprocal connections with the prefrontal cortex (PFC), integrating cognitive...
2.
Bolduc P, Pfaffenbach M, Evans R, Xin Z, Henry K, Gao F, et al.
ACS Med Chem Lett
. 2024 May;
15(5):714-721.
PMID: 38746903
We herein report the discovery, synthesis, and evolution of a series of indazoles and azaindazoles as CNS-penetrant IRAK4 inhibitors. Described is the use of structure-based and property-based drug design strategically...
3.
Pfaffenbach M, Bolduc P, Xin Z, Gao F, Evans R, Fang T, et al.
J Med Chem
. 2024 May;
67(10):8383-8395.
PMID: 38695469
Interleukin receptor associated kinase 4 (IRAK4) plays an important role in innate immune signaling through Toll-like and interleukin-1 receptors and represents an attractive target for the treatment of inflammatory diseases...
4.
Pellerin K, Rubino S, Burns J, Smith B, Mccarl C, Zhu J, et al.
Brain
. 2021 Jun;
144(8):2361-2374.
PMID: 34145876
Autoantibodies are a hallmark of numerous neurological disorders, including multiple sclerosis, autoimmune encephalitides and neuromyelitis optica. Whilst well understood in peripheral myeloid cells, the pathophysiological significance of autoantibody-induced Fc receptor...
5.
Vrselja Z, Daniele S, Silbereis J, Talpo F, Morozov Y, Sousa A, et al.
Nature
. 2019 Apr;
568(7752):336-343.
PMID: 30996318
The brains of humans and other mammals are highly vulnerable to interruptions in blood flow and decreases in oxygen levels. Here we describe the restoration and maintenance of microcirculation and...
6.
Salmaso N, Silbereis J, Komitova M, Mitchell P, Chapman K, Ment L, et al.
J Neurosci
. 2012 Jun;
32(26):8930-9.
PMID: 22745493
Premature children born with very low birth weight (VLBW) can suffer chronic hypoxic injury as a consequence of abnormal lung development and cardiovascular abnormalities, often leading to grave neurological and...
7.
Bi B, Salmaso N, Komitova M, Simonini M, Silbereis J, Cheng E, et al.
J Neurosci
. 2011 Jun;
31(25):9205-21.
PMID: 21697371
Glial fibrillary acidic protein-positive (GFAP(+)) cells give rise to new neurons in the neurogenic niches; whether they are able to generate neurons in the cortical parenchyma is not known. Here,...
8.
Silbereis J, Heintz T, Taylor M, Ganat Y, Ment L, Bordey A, et al.
Mol Cell Neurosci
. 2010 May;
44(4):362-73.
PMID: 20470892
It is well established that cerebellar granule cell precursors (GCPs) initially derive from progenitors in the rhombic lip of the embryonic cerebellar primordium. GCPs proliferate and migrate tangentially across the...
9.
Silbereis J, Cheng E, Ganat Y, Ment L, Vaccarino F
Stem Cells
. 2009 May;
27(5):1152-63.
PMID: 19418461
Neural stem or progenitor cells (NSC/NPCs) able to generate the different neuron and glial cell types of the cerebellum have been isolated in vitro, but their identity and location in...
10.
Fagel D, Ganat Y, Cheng E, Silbereis J, Ohkubo Y, Ment L, et al.
J Neurosci
. 2009 Jan;
29(4):1202-11.
PMID: 19176828
Chronic postnatal hypoxia causes an apparent loss of cortical neurons that is reversed during recovery (Fagel et al., 2006). The cellular and molecular mechanisms underlying this plasticity are not understood....