Yoshinori Sekiguchi
Overview
Explore the profile of Yoshinori Sekiguchi including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
105
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Recent Articles
1.
Aoyagi K, Kato S, Isaka D, Sekiguchi Y, Otoki Y, Uehara H, et al.
Food Chem X
. 2024 Apr;
21:101131.
PMID: 38566895
[This corrects the article DOI: 10.1016/j.fochx.2023.101074.].
2.
Aoyagi K, Kato S, Isaka D, Sekiguchi Y, Otoki Y, Uehara H, et al.
Food Chem X
. 2024 Jan;
21:101074.
PMID: 38223526
As known for quite a long time now, even saturated fatty acids can be oxidized at high temperatures to produce unique aroma compounds, such as 2-alkanones and lactones. Hydroperoxide positional...
3.
Matsuda S, Yamato T, Mochizuki Y, Sekiguchi Y, Ohtsuki T
Int J Environ Res Public Health
. 2020 Oct;
17(20).
PMID: 33076472
Biogasification by methane fermentation is an important and effective way to utilize beverage wastes. Beverage wastes are good feedstocks for methane fermentation because of their richness in sugars and proteins,...
4.
Chaki S, Shimazaki T, Nishiguchi M, Funakoshi T, Iijima M, Ito A, et al.
Pharmacol Biochem Behav
. 2015 Jun;
135:154-68.
PMID: 26044968
Melanin-concentrating hormone receptor 1 (MCH1 receptor) is known to be involved in the control of mood and stress, in addition to the regulation of feeding. Here, we report further evidence...
5.
Chaki S, Shimazaki T, Karasawa J, Aoki T, Kaku A, Iijima M, et al.
Psychopharmacology (Berl)
. 2015 Apr;
232(15):2849-61.
PMID: 25869273
Rationale: Since the hypofunction of the N-methyl-D-aspartate (NMDA) receptor is known to be involved in the pathophysiology of schizophrenia, the enhancement of NMDA receptor function through glycine modulatory sites is...
6.
Nishikawa-Shimono R, Sekiguchi Y, Kawamura M, Wakasugi D, Kawanishi M, Watanabe K, et al.
Chem Pharm Bull (Tokyo)
. 2014 Jun;
62(6):528-37.
PMID: 24881658
Synthesis and structure-activity relationship of a novel series of isoquinoline CRTH2 antagonists bearing a methylene linker between the isoquinoline and benzamide moieties were described. Optimization focusing on the substituents of...
7.
Oka Y, Yabuuchi T, Oi T, Kuroda S, Fujii Y, Ohtake H, et al.
Bioorg Med Chem
. 2013 Nov;
21(24):7578-83.
PMID: 24262886
Class I phosphoinositide 3-kinases (PI3Ks), particularly PI3Kγ, have become attractive drug targets for inflammatory and autoimmune disorders such as rheumatoid arthritis. Herein, we describe the synthesis and the structure-activity relationships...
8.
Nishikawa-Shimono R, Sekiguchi Y, Koami T, Kawamura M, Wakasugi D, Watanabe K, et al.
Bioorg Med Chem
. 2013 Nov;
21(24):7674-85.
PMID: 24216094
In this study, we describe the synthesis and structure-activity relationship (SAR) of a series of isoquinoline chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonists. TASP0376377 (15-20), one of the...
9.
Oka Y, Yabuuchi T, Fujii Y, Ohtake H, Wakahara S, Matsumoto K, et al.
Bioorg Med Chem Lett
. 2012 Nov;
22(24):7534-8.
PMID: 23122859
A novel series of 2-aminothiazole-oxazoles was designed and synthesized as part of efforts to develop potent phosphoinositide 3-kinase γ (PI3Kγ) inhibitors. The modification of a high-throughput screening hit, compound 1,...
10.
Amada H, Sekiguchi Y, Ono N, Koami T, Takayama T, Yabuuchi T, et al.
Bioorg Med Chem
. 2012 Nov;
20(24):7128-38.
PMID: 23117174
A series of 5-(1,3-benzothiazol-6-yl)-4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazole derivatives was synthesized as transforming growth factor-β (TGF-β) type I receptor (also known as activin-like kinase 5 or ALK5) inhibitors. These compounds were evaluated for their...