Yoshihiro Kubo
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Explore the profile of Yoshihiro Kubo including associated specialties, affiliations and a list of published articles.
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95
Citations
1573
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Recent Articles
1.
Fukuzawa S, Kawaguchi T, Shimomura T, Kubo Y, Tsukamoto H
Biochemistry
. 2025 Feb;
64(5):1020-1031.
PMID: 39947647
Ciliary opsins (c-opsin) have been identified not only in vertebrates but also in invertebrates. An invertebrate ciliary opsin was recently identified in the fan worm (formerly named ); however, its...
2.
Liu C, Chen I, Barri M, Murrell-Lagnado R, Kubo Y
J Biol Chem
. 2024 Nov;
300(12):108006.
PMID: 39551139
Sigma-1 receptor (S1R) is a multimodal chaperone protein that is implicated in various pathophysiological conditions including drug addiction, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS). S1R interacts with various ion...
3.
Hagihara H, Shoji H, Hattori S, Sala G, Takamiya Y, Tanaka M, et al.
Elife
. 2024 Mar;
12.
PMID: 38529532
Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These changes in lactate levels can result in...
4.
Liu C, Chen I, Tateyama M, Kubo Y
J Biol Chem
. 2024 Mar;
300(5):107219.
PMID: 38522516
G-protein-gated inward rectifier K (GIRK) channels play a critical role in the regulation of the excitability of cardiomyocytes and neurons and include GIRK1, GIRK2, GIRK3 and GIRK4 subfamily members. BD1047...
5.
Tsukamoto H, Kubo Y
Proc Natl Acad Sci U S A
. 2023 May;
120(21):e2301269120.
PMID: 37186850
Animal opsins, light-sensitive G protein-coupled receptors, have been used for optogenetic tools to control G protein-dependent signaling pathways. Upon G protein activation, the Gα and Gβγ subunits drive different intracellular...
6.
Hori S, Tateyama M, Shirai T, Kubo Y, Saitoh O
Nat Commun
. 2023 May;
14(1):2415.
PMID: 37169739
TRPV1 plays an important role in the thermosensory system; however, the mechanism controlling its heat activation property is not well understood. Here, we determine the heat activation properties of TRPV1...
7.
Tateyama M, Kubo Y
PLoS One
. 2023 Apr;
18(4):e0284962.
PMID: 37099539
A member of THIK (two pore domain halothane-inhibited K+) channels, THIK-1, was reported as a target of Gi/o-coupled receptors (Gi/o-Rs) in neurons and microglia. We confirmed that in HEK293T cells...
8.
9.
Shimomura T, Hirazawa K, Kubo Y
Proc Natl Acad Sci U S A
. 2023 Feb;
120(6):e2209569120.
PMID: 36724253
Two-pore channels (TPCs) are activated by phosphatidylinositol bisphosphate (PIP) binding to domain I and/or by voltage sensing in domain II (DII). Little is known about how these two stimuli are...
10.
Tsuboi D, Otsuka T, Shimomura T, Faruk M, Yamahashi Y, Amano M, et al.
Cell Rep
. 2022 Sep;
40(10):111309.
PMID: 36070693
Dysfunctional dopamine signaling is implicated in various neuropsychological disorders. Previously, we reported that dopamine increases D1 receptor (D1R)-expressing medium spiny neuron (MSN) excitability and firing rates in the nucleus accumbens...