Yongshun Chen
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Explore the profile of Yongshun Chen including associated specialties, affiliations and a list of published articles.
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Articles
66
Citations
3461
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Recent Articles
11.
Wang H, Zhou J, Lei J, Mo G, Wu Y, Liu H, et al.
PLoS Biol
. 2024 May;
22(5):e3002619.
PMID: 38814985
The CRISPR-associated endonuclease Cas12a has become a powerful genome-editing tool in biomedical research due to its ease of use and low off-targeting. However, the size of Cas12a severely limits clinical...
12.
Cai Y, Xia L, Zhu H, Cheng H, Tian Y, Sun L, et al.
Cell Signal
. 2024 Apr;
119:111155.
PMID: 38565413
Background: Esophageal cancer (EC) is highly ranked among all cancers in terms of its incidence and mortality rates. MicroRNAs (miRNAs) are considered to play key regulatory parts in EC. Multiple...
13.
Chen P, Zhou J, Liu H, Zhou E, He B, Wu Y, et al.
PLoS Biol
. 2024 Mar;
22(3):e3002514.
PMID: 38483978
The clustered regularly interspaced short palindromic repeat (CRISPR)-Cas12a system is a powerful tool in gene editing; however, crRNA-DNA mismatches might induce unwanted cleavage events, especially at the distal end of...
14.
Fang J, Lei J, He B, Wu Y, Chen P, Sun Z, et al.
J Transl Med
. 2024 Feb;
22(1):203.
PMID: 38403590
Resident memory T (Trm) cells which are specifically located in non-lymphoid tissues showed distinct phenotypes and functions compared to circulating memory T cells and were vital for the initiation of...
15.
Zhao W, Lei J, Ke S, Chen Y, Xiao J, Tang Z, et al.
EClinicalMedicine
. 2023 Nov;
66:102315.
PMID: 38024475
Background: Immunotherapy has revolutionized the treatment of cancer. However, microsatellite stable (MSS) metastatic colorectal cancer (mCRC) shows a low response to PD-1 inhibitors. Antiangiogenic therapy can enhance anti-PD-1 efficacy, but...
16.
Tian Y, Shi Z, Wang C, Ke S, Qiu H, Zhao W, et al.
Ann Surg Oncol
. 2023 Nov;
31(2):860-871.
PMID: 37947979
Background: Neoadjuvant chemoradiotherapy (NCRT) is recommended as the treatment standard for locally advanced esophageal squamous cell carcinoma (ESCC). The use of immunotherapy in the neoadjuvant setting has gained attention. Multiple,...
17.
Hu Y, Zhou M, Tang J, Li S, Liu H, Hu J, et al.
Clin Cancer Res
. 2023 Aug;
29(20):4088-4097.
PMID: 37556120
Purpose: This study aimed to evaluate the efficacy and safety of camrelizumab plus apatinib with or without stereotactic body radiotherapy (SBRT) as first-line therapy for patients with hepatocellular carcinoma (HCC)...
18.
Lei J, Zhou Z, Fang J, Sun Z, He M, He B, et al.
Int Immunopharmacol
. 2023 Jun;
121:110350.
PMID: 37290325
The use of aspirin is associated with reduced incidence of colorectal cancer (CRC). However, the detailed mechanism remains unclear. In this study, we reported that colon cancer cells treated with...
19.
San D, Lei J, Liu Y, Jing B, Ye X, Wei P, et al.
Cell Insight
. 2023 May;
2(1):100076.
PMID: 37192909
Evidence shows that some class I human leucocyte antigen (HLA) alleles are related to durable HIV controls. The T18A TCR, which has the alloreactivity between HLA-B∗42:01 and HLA-B∗81:01 and the...
20.
Fan X, Wang J, Xia L, Qiu H, Tian Y, Zhangcai Y, et al.
Int J Surg
. 2023 May;
109(6):1708-1719.
PMID: 37132192
Background: The efficacy of endoscopic therapy on the long-term survival outcomes of T1b oesophageal cancer (EC) is unclear, this study was designed to clarify the survival outcomes of endoscopic therapy...