Yonglei Shang
Overview
Explore the profile of Yonglei Shang including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
478
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0
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Recent Articles
1.
Hsiao Y, Wallweber H, Alberstein R, Lin Z, Du C, Etxeberria A, et al.
Nat Commun
. 2024 Sep;
15(1):8382.
PMID: 39333507
We describe a process for rapid antibody affinity optimization by repertoire mining to identify clones across B cell clonal lineages based on convergent immune responses where antigen-specific clones with the...
2.
Segaliny A, Jayaraman J, Chen X, Chong J, Luxon R, Fung A, et al.
Commun Biol
. 2023 Apr;
6(1):380.
PMID: 37029216
Bispecific antibodies (BsAbs) represent an emerging class of immunotherapy, but inefficiency in the current discovery has limited their broad clinical availability. Here we report a high throughput, agnostic, single-cell-based functional...
3.
Sengupta-Ghosh A, Dominguez S, Xie L, Barck K, Jiang Z, Earr T, et al.
Neurobiol Dis
. 2019 Sep;
132:104558.
PMID: 31471201
No abstract available.
4.
5.
Hsiao Y, Shang Y, Dicara D, Yee A, Lai J, Kim S, et al.
MAbs
. 2019 Mar;
11(4):735-746.
PMID: 30900945
Traditional hybridoma and B cell cloning antibody discovery platforms have inherent limits in immune repertoire sampling depth. One consequence is that monoclonal antibody (mAb) leads often lack the necessary affinity...
6.
Sengupta-Ghosh A, Dominguez S, Xie L, Barck K, Jiang Z, Earr T, et al.
Neurobiol Dis
. 2018 Dec;
124:340-352.
PMID: 30528255
Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons, is characterized by rapid decline of motor function and ultimately respiratory failure. As motor neuron death occurs late in the...
7.
Chen Y, Kim S, Shang Y, Guillory J, Stinson J, Zhang Q, et al.
J Immunol Methods
. 2018 Jan;
455:88-94.
PMID: 29357282
Since the invention of Hybridoma technology by Milstein and Köhler in 1975, its application has greatly advanced the antibody discovery process. The technology enables both functional screening and long-term archival...
8.
Huang T, Hazen M, Shang Y, Zhou M, Wu X, Yan D, et al.
JCI Insight
. 2016 Oct;
1(7):e86689.
PMID: 27699264
Eosinophilic inflammation and Th2 cytokine production are central to the pathogenesis of asthma. Agents that target either eosinophils or single Th2 cytokines have shown benefits in subsets of biomarker-positive patients....
9.
Bumbaca Yadav D, Sharma V, Boswell C, Hotzel I, Tesar D, Shang Y, et al.
J Biol Chem
. 2015 Oct;
290(50):29732-41.
PMID: 26491012
The pharmacokinetic (PK) behavior of monoclonal antibodies in cynomolgus monkeys (cynos) is generally translatable to that in humans. Unfortunately, about 39% of the antibodies evaluated for PKs in cynos have...
10.
Shang Y, Tesar D, Hotzel I
Protein Eng Des Sel
. 2015 Apr;
28(10):437-44.
PMID: 25855659
A recently described dual-host phage display vector that allows expression of immunoglobulin G (IgG) in mammalian cells bypasses the need for subcloning of phage display clone inserts to mammalian vectors...