Yongchang Chang
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Explore the profile of Yongchang Chang including associated specialties, affiliations and a list of published articles.
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51
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1161
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Recent Articles
1.
Idikuda V, Roy Chowdhury S, Chang Y, Ren Q, Bao H, Goldsmith R, et al.
bioRxiv
. 2025 Jan;
PMID: 39763952
In the human heart, the binding of cyclic adenosine monophosphate (cAMP), a second messenger, to hyperpolarization and cyclic nucleotide-gated (HCN) regulates the automaticity of pacemaker cells. Recent single-molecule binding studies...
2.
Burtscher V, Wang L, Cowgill J, Chen Z, Edge C, Smith E, et al.
Sci Adv
. 2025 Jan;
11(1):eadr7427.
PMID: 39752505
Hyperpolarization-activated and cyclic nucleotide-gated (HCN) ion channels are members of the cyclic nucleotide-binding family and are crucial for regulating cellular automaticity in many excitable cells. HCN channel activation contributes to...
3.
Burtscher V, Mount J, Huang J, Cowgill J, Chang Y, Bickel K, et al.
Nat Commun
. 2024 Jun;
15(1):5216.
PMID: 38890331
Hyperpolarization and cyclic nucleotide (HCN) activated ion channels are critical for the automaticity of action potentials in pacemaking and rhythmic electrical circuits in the human body. Unlike most voltage-gated ion...
4.
Lin J, Chang Y, Tewari D, Cowgill J, Chanda B
Biophys J
. 2024 Apr;
123(14):2176-2184.
PMID: 38678368
Ion channels of the cyclic nucleotide-binding domain (CNBD) family play a crucial role in the regulation of key biological processes, such as photoreception and pacemaking activity in the heart. These...
5.
Burtscher V, Mount J, Cowgill J, Chang Y, Bickel K, Yuan P, et al.
bioRxiv
. 2023 Aug;
PMID: 37645882
Hyperpolarization and cyclic-nucleotide (HCN) activated ion channels play a critical role in generating self-propagating action potentials in pacemaking and rhythmic electrical circuits in the human body. Unlike most voltage-gated ion...
6.
Zhao R, Ali G, Nie H, Chang Y, Bhattarai D, Su X, et al.
Br J Pharmacol
. 2020 Mar;
177(13):3091-3106.
PMID: 32133621
Background And Purpose: Lung oedema in association with suppressed fibrinolysis is a hallmark of lung injury. Here, we have tested whether plasmin cleaves epithelial sodium channels (ENaC) to resolve lung...
7.
Zhao R, Ali G, Chang J, Komatsu S, Tsukasaki Y, Nie H, et al.
Theranostics
. 2019 Nov;
9(26):8155-8170.
PMID: 31754387
Lung epithelial sodium channel (ENaC) encoded by genes is essential for maintaining transepithelial salt and fluid homeostasis in the airway and the lung. Compared to α, β, and γ subunits,...
8.
Ren X, Zhao Y, Xue F, Zheng Y, Huang H, Wang W, et al.
Mol Ther Nucleic Acids
. 2019 Aug;
17:726-740.
PMID: 31437653
The α-synuclein aggregates are the main component of Lewy bodies in Parkinson's disease (PD) brain, and they showed immunotherapy could be employed to alleviate α-synuclein aggregate pathology in PD. Recently...
9.
Chen D, Gao F, Ma X, Brek Eaton J, Huang Y, Gao M, et al.
Front Pharmacol
. 2019 Mar;
10:72.
PMID: 30837868
Alpha6-containing nicotinic acetylcholine receptors are primarily found in neurons of the midbrain dopaminergic (DA) system, suggesting these receptors are potentially involved in drug reward and dependence. Here, we report a...
10.
Gao F, Chen D, Ma X, Sudweeks S, Yorgason J, Gao M, et al.
Neuropharmacology
. 2019 Feb;
149:45-54.
PMID: 30710570
Alcohol use disorder (AUD) is a serious public health problem that results in tremendous social, legal and medical costs to society. Unlike other addictive drugs, there is no specific molecular...