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Yongbo Hu

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Articles 65
Citations 776
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Recent Articles
1.
Xie S, Tai C, Morton C, Ma L, Huang S, Wittlin S, et al.
PLoS Pathog . 2024 Dec; 20(12):e1012429. PMID: 39652589
The Plasmodium falciparum cytoplasmic tyrosine tRNA synthetase (PfTyrRS) is an attractive drug target that is susceptible to reaction-hijacking by AMP-mimicking nucleoside sulfamates. We previously identified an exemplar pyrazolopyrimidine ribose sulfamate,...
2.
Zhang Q, Zhang A, Zhao Z, Li Q, Hu Y, Huang X, et al.
Prog Neuropsychopharmacol Biol Psychiatry . 2024 Dec; 136():111211. PMID: 39642975
Introduction: Major depressive disorder (MDD) is a debilitating and heterogeneous disease. Many MDD patients experience concurrent anxiety symptoms, often referred to as anxious depression (MDD-ANX). The relationships between network alterations...
3.
Zhang Q, Zhang A, Zhao Z, Li Q, Hu Y, Huang X, et al.
J Affect Disord . 2024 Nov; 370:249-259. PMID: 39500466
Background: Subcortical functional abnormalities are believed to contribute to clinical symptoms and cognitive impairments in major depressive disorder (MDD). By introducing functional gradient mapping, the present study evaluated subcortical gradients...
4.
Song C, Huang W, Zhang P, Shi J, Yu T, Wang J, et al.
Transl Neurodegener . 2024 Nov; 13(1):54. PMID: 39497162
Background: Lysosomal homeostasis and functions are essential for the survival of neural cells. Impaired lysosomal biogenesis and acidification in Alzheimer's disease (AD) pathogenesis leads to proteolytic dysfunction and neurodegeneration. However,...
5.
Lu W, Liu F, Zhang Y, He X, Hu Y, Xu H, et al.
BMJ Ment Health . 2024 Jul; 27(1. PMID: 39079887
Background: Behavioural and psychological symptoms of dementia (BPSD) are highly prevalent in people living with dementia. Second-generation antipsychotics (SGAs) are commonly used to treat BPSD, but their comparative efficacy and...
6.
Li Q, Zhao Y, Hu Y, Liu Y, Wang Y, Zhang Q, et al.
EBioMedicine . 2024 Jul; 106:105255. PMID: 39032426
Background: Controllability analysis is an approach developed for evaluating the ability of a brain region to modulate function in other regions, which has been found to be altered in major...
7.
Wang L, Bao Y, Duan X, Li H, Ding H, Yu F, et al.
J Transl Med . 2024 Jul; 22(1):635. PMID: 38978048
Background: Circadian rhythm (CR) disturbance is intricately associated with Parkinson's disease (PD). However, the involvement of CR-related mechanisms in the pathogenesis and progression of PD remains elusive. Methods: A total...
8.
Yang X, Fang S, Lyu W, Hu Y, Xu H, Jiang X, et al.
Psychiatry Clin Neurosci . 2024 Jul; 78(9):536-545. PMID: 38957929
Aim: Major depressive disorder (MDD) is a prevalent psychiatric condition and vortioxetine offers promising antidepressant effects due to its unique pharmacological profile. However, the dose-response relationships of vortioxetine for MDD...
9.
Zhang N, Li J, Dong Z, Hu Y, Zhong Z, Gong Q, et al.
Front Psychiatry . 2024 May; 15:1362612. PMID: 38742130
Introduction: Major depressive disorder (MDD) is partially inheritable while its mechanism is still uncertain. Methods: This cross-sectional study focused on gene pathways as a whole rather than polymorphisms of single...
10.
Zhang L, Hu X, Hu Y, Tang M, Qiu H, Zhu Z, et al.
Psychoradiology . 2024 Apr; 2(4):190-198. PMID: 38665275
Background: The hippocampus and amygdala are densely interconnected structures that work together in multiple affective and cognitive processes that are important to the etiology of major depressive disorder (MDD). Each...