Yong-Sil Lee
Overview
Explore the profile of Yong-Sil Lee including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
51
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Recent Articles
1.
Suh Y, Lee Y, Kim S, Jung J, Yun H, Jang J, et al.
Org Biomol Chem
. 2011 Nov;
10(3):561-8.
PMID: 22108849
A novel and stereo-controlled method for the preparation of functionalized macrolactams was developed. The process involves stereoselective enol ether formation, followed by an azacyclic ring expansion via an aza-Claisen rearrangement....
2.
Lee Y, Jung J, Kim S, Jung J, Paek S, Kim N, et al.
Org Lett
. 2010 Mar;
12(9):2040-3.
PMID: 20345160
The first asymmetric total synthesis of fluvirucinine A(2) has been accomplished. A key feature of the synthesis is an iterative lactam ring expansion to provide rapid access to the 14-membered...
3.
Suh Y, Lee Y, Min K, Park O, Kim J, Seung H, et al.
J Med Chem
. 2005 Sep;
48(18):5823-36.
PMID: 16134949
Recently, 1,3-diarylalkyl thioureas have merged as one of the promising nonvanilloid TRPV1 antagonists possessing excellent therapeutic potential in pain regulation. In this paper, the full structure-activity relationship for TRPV1 antagonism...
4.
Paek S, Seo S, Kim S, Jung J, Lee Y, Jung J, et al.
Org Lett
. 2005 Jul;
7(15):3159-62.
PMID: 16018610
[reaction: see text]. Unified and highly convergent total syntheses of (+)-macrosphelides A and B are described. Key features of the syntheses include (1) concise synthesis of the optically active delta-hydroxy-gamma-keto...
5.
Lee J, Kang S, Kil M, Shin M, Lim J, Choi H, et al.
Bioorg Med Chem Lett
. 2005 Jul;
15(18):4136-42.
PMID: 16005215
The structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues have been investigated as TRPV1 receptor antagonists. The 2-halogen analogues showed enhanced antagonism compared to the prototype antagonist.
6.
Lee J, Jin M, Kang S, Kim S, Lee J, Shin M, et al.
Bioorg Med Chem Lett
. 2005 Jul;
15(18):4143-50.
PMID: 15993063
The structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues have been investigated as TRPV1 receptor antagonists. A docking model of potent antagonist 2 with the sensor region of TRPV1 is...
7.
Shin D, Kim S, Chae J, Hyun S, Seo S, Lee Y, et al.
Bioorg Med Chem Lett
. 2004 Sep;
14(17):4519-23.
PMID: 15357984
Syntheses and excellent anti-MRSA activities of the mansonone F analogs are reported. In addition, the minimal structural requirements for its anti-MRSA activities as well as its structure-activity relationship including the...
8.
Lee K, Park H, Kim Y, Seo S, Lee Y, Moon S, et al.
Arch Pharm Res
. 2004 Jun;
27(5):467-70.
PMID: 15202549
Comparative molecular field analysis and comparative molecular similarity indices analysis were performed on twenty five analogues of pimarane COX-2 inhibitor to optimize their cyclooxygenase-2 (COX-2) selective anti-inflammatory activities.
9.
Suh Y, Lee K, Moon S, Seo S, Lee Y, Kim S, et al.
Bioorg Med Chem Lett
. 2004 Jun;
14(13):3487-90.
PMID: 15177458
Syntheses and excellent anti-inflammatory effects of a series of novel acanthoic acid analogs are reported. In particular, the mechanistic basis for their anti-inflammatory effects is also described.
10.
Seo S, Jung J, Paek S, Lee Y, Kim S, Lee K, et al.
Org Lett
. 2004 Jan;
6(3):429-32.
PMID: 14748610
[reaction: see text] The asymmetric total synthesis of bacillariolide III has been achieved via 15 linear steps in 14.6% overall yield. The key feature of this synthetic route involves the...