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Yoichi Shinkai

Explore the profile of Yoichi Shinkai including associated specialties, affiliations and a list of published articles. Areas
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Articles 153
Citations 8576
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Recent Articles
1.
Yamashita M, Ogawa C, Zhang B, Kobayashi T, Nomura A, Barker C, et al.
Nat Commun . 2024 Nov; 15(1):10129. PMID: 39613744
Despite its broad application in in vitro studies, the application of targeted protein degradation (TPD) to animal models faces considerable challenges. Here, we develop inducible and cell-type specific TPD systems...
2.
Shinkai A, Hashimoto H, Shimura C, Fujimoto H, Fukuda K, Horikoshi N, et al.
Nucleic Acids Res . 2024 Aug; 52(17):10194-10219. PMID: 39142653
The chromatin-remodeling enzyme helicase lymphoid-specific (HELLS) interacts with cell division cycle-associated 7 (CDCA7) on nucleosomes and is involved in the regulation of DNA methylation in higher organisms. Mutations in these...
3.
Rots D, Bouman A, Yamada A, Levy M, Dingemans A, de Vries B, et al.
Am J Hum Genet . 2024 Jul; 111(8):1605-1625. PMID: 39013458
The shift to a genotype-first approach in genetic diagnostics has revolutionized our understanding of neurodevelopmental disorders, expanding both their molecular and phenotypic spectra. Kleefstra syndrome (KLEFS1) is caused by EHMT1...
4.
Ideno H, Nakashima K, Komatsu K, Araki R, Abe M, Arai Y, et al.
Bone . 2024 Jan; 180:117000. PMID: 38172016
No abstract available.
5.
Ideno H, Nakashima K, Komatsu K, Kimura H, Shinkai Y, Tachibana M, et al.
J Oral Biosci . 2023 Dec; 66(1):35-40. PMID: 38142940
Objectives: The tongue comprises multiple tissues of different embryonic origins, including pharyngeal arch, somite, and cranial neural crest (CNC). However, its developmental regulatory mechanisms, especially those involving epigenetic modifiers, remain...
6.
Kuramochi M, Sugawara I, Shinkai Y, Mio K, Sasaki Y
Int J Mol Sci . 2023 Dec; 24(23). PMID: 38069236
Understanding the cellular environment as molecular crowding that supports the structure-specific functional expression of biomolecules has recently attracted much attention. Time-resolved X-ray observations have the remarkable capability to capture the...
7.
Yamatoya K, Kurosawa M, Hirose M, Miura Y, Taka H, Nakano T, et al.
Biol Reprod . 2023 Nov; 110(3):465-475. PMID: 37995271
The mammalian oviductal lumen is a specialized chamber that provides an environment that strictly regulates fertilization and early embryogenesis, but the regulatory mechanisms to gametes and zygotes are unclear. We...
8.
Shimazu T, Yoshimoto R, Kotoshiba K, Suzuki T, Matoba S, Hirose M, et al.
Genes Dev . 2023 Aug; 37(15-16):724-742. PMID: 37612136
Histidine (His) residues are methylated in various proteins, but their roles and regulation mechanisms remain unknown. Here, we show that carnosine N-methyltransferase 1 (CARNMT1), a known His methyltransferase of dipeptide...
9.
Fukuda K, Shimi T, Shimura C, Ono T, Suzuki T, Onoue K, et al.
Nucleic Acids Res . 2023 May; 51(12):6190-6207. PMID: 37178005
Heterochromatin is a key architectural feature of eukaryotic chromosomes critical for cell type-specific gene expression and genome stability. In the mammalian nucleus, heterochromatin segregates from transcriptionally active genomic regions and...
10.
Itai T, Sugie A, Nitta Y, Maki R, Suzuki T, Shinkai Y, et al.
Sci Rep . 2023 Mar; 13(1):3954. PMID: 36894578
No abstract available.