Yoga Srinivasan
Overview
Explore the profile of Yoga Srinivasan including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
609
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0
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Recent Articles
1.
Bokoch M, Jo H, Valcourt J, Srinivasan Y, Pan A, Capponi S, et al.
Biochemistry
. 2018 Aug;
57(39):5748-5758.
PMID: 30102523
The pathways that G protein-coupled receptor (GPCR) ligands follow as they bind to or dissociate from their receptors are largely unknown. Protease-activated receptor-1 (PAR1) is a GPCR activated by intramolecular...
2.
Schepis A, Barker A, Srinivasan Y, Balouch E, Zheng Y, Lam I, et al.
J Cell Biol
. 2018 Jan;
217(3):1097-1112.
PMID: 29301867
Mechanisms that sense and regulate epithelial morphogenesis, integrity, and homeostasis are incompletely understood. Protease-activated receptor 2 (Par2), the Par2-activating membrane-tethered protease matriptase, and its inhibitor, hepatocyte activator inhibitor 1 (Hai1),...
3.
Zhang C, Srinivasan Y, Arlow D, Fung J, Palmer D, Zheng Y, et al.
Nature
. 2012 Dec;
492(7429):387-92.
PMID: 23222541
Protease-activated receptor 1 (PAR1) is the prototypical member of a family of G-protein-coupled receptors that mediate cellular responses to thrombin and related proteases. Thrombin irreversibly activates PAR1 by cleaving the...
4.
Camerer E, Barker A, Duong D, Ganesan R, Kataoka H, Cornelissen I, et al.
Dev Cell
. 2010 Feb;
18(1):25-38.
PMID: 20152175
We report an unexpected role for protease signaling in neural tube closure and the formation of the central nervous system. Mouse embryos lacking protease-activated receptors 1 and 2 showed defective...
5.
Camerer E, Regard J, Cornelissen I, Srinivasan Y, Duong D, Palmer D, et al.
J Clin Invest
. 2009 Jul;
119(7):1871-9.
PMID: 19603543
Maintenance of vascular integrity is critical for homeostasis, and temporally and spatially regulated vascular leak is a central feature of inflammation. Sphingosine-1-phosphate (S1P) can regulate endothelial barrier function, but the...
6.
Ludeman M, Kataoka H, Srinivasan Y, Esmon N, Esmon C, Coughlin S
J Biol Chem
. 2005 Jan;
280(13):13122-8.
PMID: 15665002
Activated protein C (APC), a natural anticoagulant protease, can trigger cellular responses via protease-activated receptor-1 (PAR1), a G protein-coupled receptor for thrombin. Whether this phenomenon contributes to the physiological effects...