Yingqun Huang
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Explore the profile of Yingqun Huang including associated specialties, affiliations and a list of published articles.
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44
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2598
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Recent Articles
1.
Lv H, Liu B, Dai Y, Li F, Bellone S, Zhou Y, et al.
J Clin Invest
. 2024 Aug;
134(21).
PMID: 39141428
Endometriosis is a debilitating, chronic inflammatory disease affecting approximately 10% of reproductive-age women worldwide with no cure. While macrophages have been intrinsically linked to the pathophysiology of endometriosis, targeting them...
2.
Li D, Huang Y
Trends Cell Biol
. 2024 Jul;
34(8):620-621.
PMID: 38964955
Multiple mechanisms have been reported for how circular RNAs (circRNAs) are exported to the cytoplasm. A recent paper by Cao et al. shows that export of a subset of circRNAs...
3.
Liu B, Xie D, Huang X, Jin S, Dai Y, Sun X, et al.
Diabetologia
. 2024 Jan;
67(4):724-737.
PMID: 38216792
Aim/hypothesis: The peroxisome proliferator-activated receptor-γ coactivator α (PGC-1α) plays a critical role in the maintenance of glucose, lipid and energy homeostasis by orchestrating metabolic programs in multiple tissues in response...
4.
Song J, Lv H, Liu B, Hao M, Taylor H, Zhang X, et al.
Mol Metab
. 2023 Oct;
78:101828.
PMID: 37898449
Objective: FAS-mediated apoptosis of hepatocytes and aberrant TGF-β signaling are major drivers of liver fibrosis. Decreased miRNA let-7 expression in the livers of patients and animals with fibrosis suggests a...
5.
Lv H, Catarino J, Li D, Liu B, Gao X, Horvath T, et al.
Proc Natl Acad Sci U S A
. 2023 Apr;
120(16):e2300015120.
PMID: 37036983
Anorexia nervosa (AN) is a psychiatric illness with the highest mortality. Current treatment options have been limited to psychotherapy and nutritional support, with low efficacy and high relapse rates. Hypothalamic...
6.
Xie D, Stutz B, Li F, Chen F, Lv H, Sestan-Pesa M, et al.
J Clin Invest
. 2022 Oct;
132(19).
PMID: 36189793
The TET family of dioxygenases promote DNA demethylation by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC). Hypothalamic agouti-related peptide-expressing (AGRP-expressing) neurons play an essential role in driving feeding, while also modulating nonfeeding...
7.
Xie D, Chen F, Zhang Y, Shi B, Song J, Chaudhari K, et al.
Proc Natl Acad Sci U S A
. 2022 Mar;
119(14):e2122217119.
PMID: 35344434
SignificanceA clear mechanistic understanding of metformin's antidiabetic effects is lacking. This is because suprapharmacological concentrations of metformin have been used in most studies. Using mouse models and human primary hepatocytes,...
8.
Cao T, Jiang Y, Li D, Sun X, Zhang Y, Qin L, et al.
FASEB J
. 2020 May;
34(6):8625-8640.
PMID: 32374060
While emerging evidence suggests the link between endothelial activation of TGF-β signaling, induction of endothelial-to-mesenchymal transition (EndMT), and cardiovascular disease (CVD), the molecular underpinning of this connection remains enigmatic. Here,...
9.
Xu Y, Sun X, Zhang R, Cao T, Cai S, Boyer J, et al.
Cell Rep
. 2020 Feb;
30(5):1310-1318.e5.
PMID: 32023451
Pathological activation of TGF-β signaling is universal in fibrosis. Aberrant TGF-β signaling in conjunction with transdifferentiation of hepatic stellate cells (HSCs) into fibrogenic myofibroblasts plays a central role in liver...
10.
Li D, Cao T, Sun X, Jin S, Xie D, Huang X, et al.
Nat Commun
. 2020 Jan;
11(1):342.
PMID: 31953394
Precise control of hepatic glucose production (HGP) is pivotal to maintain systemic glucose homeostasis. HNF4α functions to stimulate transcription of key gluconeogenic genes. HNF4α harbors two promoters (P2 and P1)...