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Yiguo Zhang

Explore the profile of Yiguo Zhang including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 70
Citations 1088
Followers 0
Related Specialties
Biochemistry
Oncology
Cell Biology
Top 10 Co-Authors
Shaofan Hu
Lu Qiu
Meng Wang
Yuancai Xiang
Zigang Dong
Ann M Bode
Zhengwen Zhang
Yonggang Ren
Keli Liu
John D Hayes
Published In
J Biol Chem
Biochem J
Sci Rep
PLoS One
Int J Mol Sci
Affiliations
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Recent Articles
1.
Deficiency of DDI2 suppresses liver cancer progression by worsening cell survival conditions
Liu K, Hu S, Wufuer R, Zhang Q, Qiu L, Zhang Z, et al.
Free Radic Biol Med . 2025 Mar; 232:200-213. PMID: 40049338
The levels of reactive oxygen species (ROS) and the extent of ensuing DNA damage significantly influence cancer initiation and progression. Of crucial importance, the aspartate protease DDI2 has been proposed...
2.
Genetic loss of Nrf1 and Nrf2 leads to distinct metabolism reprogramming of HepG2 cells by opposing regulation of the PI3K-AKT-mTOR signalling pathway
Deng R, Zhu Y, Liu K, Zhang Q, Hu S, Wang M, et al.
Bioorg Chem . 2024 Feb; 145:107212. PMID: 38377819
As a vital hallmarker of cancer, the metabolic reprogramming has been shown to play a pivotal role in tumour occurrence, metastasis and drug resistance. Amongst a vast variety of signalling...
3.
Distinct mechanisms by which Nrf1 and Nrf2 as drug targets contribute to the anticancer efficacy of cisplatin on hepatoma cells
Wufuer R, Liu K, Feng J, Wang M, Hu S, Chen F, et al.
Free Radic Biol Med . 2024 Jan; 213:488-511. PMID: 38278308
Cisplatin (cis-Dichlorodiamineplatinum[II], CDDP) is generally accepted as a platinum-based alkylating agent type of the DNA-damaging anticancer drug, which is widely administrated in clinical treatment of many solid tumors. The pharmacological...
4.
A novel crosstalk between Nrf2 and Smad2/3 bridged by two nuanced Keap1 isoforms with their divergent effects on these distinct family transcription factors
Chen F, Wang Q, Xiao M, Lou D, Wufur R, Hu S, et al.
Free Radic Biol Med . 2024 Jan; 213:190-207. PMID: 38242246
The Keap1-Nrf2 signalling to transcriptionally regulate antioxidant response element (ARE)-driven target genes has been accepted as key redox-sensitive pathway governing a vast variety of cellular stresses during healthy survival and...
5.
NFE2L1/Nrf1 serves as a potential therapeutical target for neurodegenerative diseases
Luczynska K, Zhang Z, Pietras T, Zhang Y, Taniguchi H
Redox Biol . 2023 Dec; 69:103003. PMID: 38150994
The failure of the proper protein turnover in the nervous system is mainly linked to a variety of neurodegenerative disorders. Therefore, a better understanding of key protein degradation through the...
6.
Nrf1 is not a direct target gene of SREBP1, albeit both are integrated into the rapamycin-responsive regulatory network in human hepatoma cells
Liu K, Hu S, Qiu L, Wang M, Zhang Z, Sun G, et al.
PLoS One . 2023 Nov; 18(11):e0294508. PMID: 38011090
The essential role of protein degradation by ubiquitin-proteasome system is exerted primarily for maintaining cellular protein homeostasis. The transcriptional activation of proteasomal genes by mTORC1 signaling depends on Nrf1, but...
7.
Loss of Nrf1 rather than Nrf2 leads to inflammatory accumulation of lipids and reactive oxygen species in human hepatoma cells, which is alleviated by 2-bromopalmitate
Deng R, Zheng Z, Hu S, Wang M, Feng J, Mattjus P, et al.
Biochim Biophys Acta Mol Cell Res . 2023 Nov; 1871(2):119644. PMID: 37996059
Since Nrf1 and Nrf2 are essential for regulating the lipid metabolism pathways, their dysregulation has thus been shown to be critically involved in the non-controllable inflammatory transformation into cancer. Herein,...
8.
Melatonin Alleviates Acute Respiratory Distress Syndrome by Inhibiting Alveolar Macrophage NLRP3 Inflammasomes Through the ROS/HIF-1α/GLUT1 Pathway
Zheng L, Zhou W, Wu Y, Xu W, Hu S, Zhang Y, et al.
Lab Invest . 2023 Oct; 103(12):100266. PMID: 37871834
Sepsis-induced acute respiratory distress syndrome (ARDS) is a devastating clinically severe respiratory disorder, and no effective therapy is available. Melatonin (MEL), an endogenous neurohormone, has shown great promise in alleviating...
9.
STC2 is a potential biomarker of hepatocellular carcinoma with its expression being upregulated in Nrf1α-deficient cells, but downregulated in Nrf2-deficient cells
Bu Q, Deng Y, Wang Q, Deng R, Hu S, Pei Z, et al.
Int J Biol Macromol . 2023 Oct; 253(Pt 8):127575. PMID: 37866563
Nrf1 (encoded by Nfe2l1) and Nrf2 (encoded by Nfe2l2), as two key members of the CNC-bZIP transcription factor, exhibit significant functional differences in their pathophysiology. Our previous findings demonstrated that...
10.
Nrf1 is an indispensable redox-determining factor for mitochondrial homeostasis by integrating multi-hierarchical regulatory networks
Hu S, Feng J, Wang M, Wufuer R, Liu K, Zhang Z, et al.
Redox Biol . 2022 Sep; 57:102470. PMID: 36174386
To defend against a vast variety of challenges in oxygenated environments, all life forms have evolutionally established a set of antioxidants, detoxification, and cytoprotective systems during natural selection and adaptive...