Yifei Geng
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Explore the profile of Yifei Geng including associated specialties, affiliations and a list of published articles.
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12
Citations
18
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Recent Articles
1.
Zhang S, Wu N, Geng Y, Guan L, Niu M, Li J, et al.
Front Pharmacol
. 2025 Mar;
16:1560559.
PMID: 40078291
Concurrent inhibition of bromodomain-containing protein 4 ( signal transductor and activator of transcription 3 (STAT3) could potentially be an effective strategy against renal cell carcinoma (RCC). Here, we successfully identified...
2.
Xu Z, Geng Y, Guan L, Niu M, Xu C, Yang L, et al.
Eur J Med Chem
. 2025 Jan;
285:117248.
PMID: 39808974
Cyclin-dependent kinase 9 (CDK9) plays a pivotal role in promoting oncogenic transcriptional pathways, significantly contributing to the development and progression of cancer. Given the unique biostability of d-amino acid, the...
3.
Liu J, Geng Y, Jiang S, Guan L, Gao J, Niu M, et al.
Front Pharmacol
. 2024 Dec;
15:1454957.
PMID: 39679370
Given that overexpression of Poly (ADP-ribose) polymerase-1 (PARP1) and Neuropilin-1 (NRP1) is implicated in the pathogenesis of human breast cancer, the design of dual PARP1/NRP1 inhibitors has wide therapeutic prospect....
4.
Ruan Y, Guan L, Wang Y, Geng Y, Wang X, Niu M, et al.
Drug Des Devel Ther
. 2024 Nov;
18:5283-5297.
PMID: 39583632
Purpose: Dual inhibition of ataxia telangiectasia mutated (ATM) and histone deacetylase 2 (HDAC2) may be a potential strategy to improve antitumor efficacy in testicular cancer. Methods: A combined virtual screening...
5.
Wang Y, Wang F, Liu W, Geng Y, Shi Y, Tian Y, et al.
Pharmacol Ther
. 2024 Nov;
264:108752.
PMID: 39557343
Natural products (NPs) have a long history as sources for drug discovery, more than half of approved drugs are related to NPs, which also exhibit multifaceted advantages in the clinical...
6.
Hua H, Guan L, Pan B, Gao J, Geng Y, Niu M, et al.
Front Pharmacol
. 2024 Oct;
15:1454523.
PMID: 39351092
Background: Overexpression of monopolar spindle 1 (MPS1) and histone deacetylase 8 (HDAC8) is associated with the proliferation of liver cancer cells, so simultaneous inhibition of both MPS1 and HDAC8 could...
7.
Luo J, Geng Y, Rana F, Fuchs G
Nat Mater
. 2024 Feb;
23(4):512-518.
PMID: 38347119
High-contrast optically detected magnetic resonance is a valuable property for reading out the spin of isolated defect colour centres at room temperature. Spin-active single defect centres have been studied in...
8.
Geng Y, Liu Y, Wang M, Dong X, Sun X, Luo Y, et al.
Front Immunol
. 2024 Jan;
14:1320475.
PMID: 38268925
Background: Ischemic stroke (IS), caused by blood and oxygen deprivation due to cerebral thrombosis, has links to activated and aggregated platelets. Discovering platelet-related biomarkers, developing diagnostic models, and screening antiplatelet...
9.
Zheng L, Zou Y, Xie T, Wu X, Tan Y, Mei S, et al.
J Med Chem
. 2023 Dec;
66(23):16187-16200.
PMID: 38093696
Dual inhibition of tubulin and neuropilin-1 (NRP1) may become an effective method for cancer treatment by simultaneously killing tumor cells and inhibiting tumor angiogenesis. Herein, we identified dual tubulin/NRP1-targeting inhibitor...
10.
Geng Y, Wang Z, Xu X, Sun X, Dong X, Luo Y, et al.
Transl Res
. 2023 Aug;
263:73-92.
PMID: 37567440
Metformin (Met), a first-line management for type 2 diabetes mellitus, has been expansively employed and studied with results indicating its therapeutic potential extending beyond glycemic control. Beyond its established role,...