Yasunao Hattori
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Explore the profile of Yasunao Hattori including associated specialties, affiliations and a list of published articles.
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44
Citations
269
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Recent Articles
1.
Kobayashi K, Taniguchi C, Tanaka M, Kimura R, Komurasaki K, Kuwano M, et al.
Bioorg Med Chem
. 2025 Feb;
120:118086.
PMID: 39922084
Verubecestat, atabecestat, and elenbecestat are small-molecule BACE1 inhibitors. Based on their structures, we designed and synthesized a novel BACE1 inhibitor with a hydroxyproline-derived N-amidinopyrrolidine scaffold. The initially synthesized derivative 7a...
2.
Awahara C, Oku D, Furuta S, Kobayashi K, Teruya K, Akaji K, et al.
Molecules
. 2025 Jan;
30(2.
PMID: 39860301
[...].
3.
Hadate Y, Hattori Y, Toda Y, Hosogi S, Okada S, Hayashi Y, et al.
Anticancer Res
. 2024 Oct;
44(11):4789-4799.
PMID: 39477320
Background/aim: Aberrant activation of the Wnt/β-catenin signaling pathway contributes to the pathogenesis of acute myelogenous leukemia (AML). Thus, targeting this pathway offers a promising therapeutic strategy against AML. Here, we...
4.
Kondo Y, Kimura H, Tanaka M, Hattori Y, Kawashima H, Takahashi K, et al.
Chemistry
. 2024 Sep;
30(71):e202403303.
PMID: 39349405
The copper-catalyzed Chan-Evans-Lam (CEL) coupling reaction advances carbon-heteroatom cross-coupling and has facilitated the development of radiohalogenation methodologies in radiochemistry. This study investigated the mechanisms and side reactions of CEL iodination...
5.
Awahara C, Oku D, Kobayashi K, Hattori Y
Chem Pharm Bull (Tokyo)
. 2024 Mar;
72(3):309-310.
PMID: 38479891
The inhibition mode of a retro-inverso (RI) inhibitor containing a hydroxyethylamine dipeptide isostere against the human T-cell leukemia virus type-1 (HTLV-1) protease was examined. Enzymatic evaluation of the RI-modified inhibitor...
6.
Omokawa M, Kimura H, Arimitsu K, Yagi Y, Hattori Y, Kawashima H, et al.
ACS Omega
. 2024 Jan;
9(1):879-886.
PMID: 38222559
We designed and synthesized a novel platinum complex conjugated with 2-fluorinated 2-deoxyglucoside, named FGC-Pt, to capitalize on the Warburg effect and metabolic trapping properties of [F]2-deoxy-2-fluoro-d-glucose (FFDG). Then, we conducted...
7.
Kondo Y, Kimura H, Chisaka R, Hattori Y, Kawashima H, Yasui H
Chem Commun (Camb)
. 2023 Dec;
60(6):714-717.
PMID: 38108251
This methodology demonstrates the ability to sequentially regulate copper-mediated radioiododeboronation and an azide-alkyne cycloaddition reaction, which facilitates the continuous incorporation of reagents into the reaction system and mediates the integration...
8.
Kondo Y, Kimura H, Sasaki M, Koike S, Yagi Y, Hattori Y, et al.
ACS Omega
. 2023 Jul;
8(27):24418-24425.
PMID: 37457489
Direct radioiodination of peptides using copper-mediated iododeboronation is a promising radiosynthetic method for solving issues of classical direct radiolabeling, such as toxicity of the organotin precursor (iododestannylation) or formation of...
9.
Nohara Y, Taniguchi K, Ii H, Masuda S, Kawakami H, Matsumoto M, et al.
Org Biomol Chem
. 2023 Jul;
21(29):5977-5984.
PMID: 37434538
While γ-glutamylcyclotransferase (GGCT) has been implicated in cancer-cell proliferation, the role of GGCT enzymatic activity in the regulation of cancer-cell growth remains unclear. Toward further understanding of GGCT , here...
10.
Sugiyama Y, Nakamura S, Tokuda Y, Nakano M, Hattori Y, Nishiguchi H, et al.
Biochem Biophys Res Commun
. 2022 Dec;
638:200-209.
PMID: 36462494
Advances in pharmacy and medicine have led to the development of many anti-cancer and molecular targeted agents; however, there are few agents capable of suppressing metastasis. To prevent cancer recurrence,...