Yasuharu Nakanishi
Overview
Explore the profile of Yasuharu Nakanishi including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
38
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Recent Articles
1.
Genetic variants of UDP-glucuronosyltransferases 1A1, 1A6, and 1A9 in cynomolgus and rhesus macaques
Uno Y, Mikami T, Tsukazaki Y, Nakanishi Y, Murayama N, Ikushiro S, et al.
Xenobiotica
. 2020 Aug;
51(1):115-121.
PMID: 32811258
1. In the cynomolgus macaque, UDP-glucuronosyltransferases (UGTs) 1As have similar molecular and enzymatic characteristics to those of their human orthologs. However, genetic polymorphisms in major cynomolgus have not been investigated....
2.
Nakanishi Y, Uno Y, Yamazaki H
Drug Metab Pharmacokinet
. 2020 Jul;
35(4):401-404.
PMID: 32651149
The cynomolgus macaque is a nonhuman primate species that is often used in drug metabolism studies during drug development. However, the localization of UDP-glucuronosyltransferases (UGTs), essential drug-metabolizing enzymes, has not...
3.
Koyanagi T, Nakanishi Y, Murayama N, Yamaura Y, Ikeda K, Yano K, et al.
Xenobiotica
. 2014 Nov;
45(4):312-21.
PMID: 25364857
1. Pharmacokinetics of human cytochrome P450 probes (caffeine, racemic warfarin, omeprazole, metoprolol and midazolam) were investigated after single intravenous and oral administrations at doses of 0.20 and 1.0 mg kg(-1),...
4.
Uehara S, Murayama N, Nakanishi Y, Nakamura C, Hashizume T, Zeldin D, et al.
Xenobiotica
. 2014 Aug;
45(2):124-30.
PMID: 25138712
1. An increasing number of studies have indicated the roles of CYP4 proteins in drug metabolism; however, CYP4 expression has not been measured in cynomolgus monkeys, an important animal species...
5.
Uehara S, Murayama N, Nakanishi Y, Nakamura C, Hashizume T, Zeldin D, et al.
Xenobiotica
. 2014 Mar;
44(9):769-74.
PMID: 24593267
The expression of small intestinal cytochromes P450 (P450s) has not been systematically measured in cynomolgus monkeys, which are widely used in preclinical drug studies to predict pharmacokinetics and toxicity in...
6.
Nakanishi Y, Yamashita H, Yoshikawa T, Tominaga T, Nojiri K, Sunaga Y, et al.
Drug Metab Pharmacokinet
. 2013 May;
28(6):510-3.
PMID: 23648676
Cynomolgus macaques, used in drug metabolism studies due to their evolutionary closeness to humans, are mainly bred in Asian countries, including Cambodia, China, and Indonesia. Cytochromes P450 (P450s) are important...
7.
Ise R, Nakanishi Y, Kohara S, Yamashita H, Yoshikawa T, Iwasaki K, et al.
Drug Metab Pharmacokinet
. 2011 Dec;
27(3):307-16.
PMID: 22166892
Cynomolgus macaques, frequently used in drug metabolism studies, are bred mainly in the countries of Asia; however, comparative studies of drug metabolism between cynomolgus macaques bred in these countries have...
8.
Uehara S, Murayama N, Nakanishi Y, Zeldin D, Yamazaki H, Uno Y
J Pharmacol Exp Ther
. 2011 Aug;
339(2):654-61.
PMID: 21849623
The cynomolgus monkey is widely used as a primate model in preclinical studies because of its evolutionary closeness to humans. Despite their importance in drug metabolism, the content of each...
9.
Nakanishi Y, Matsushita A, Matsuno K, Iwasaki K, Utoh M, Nakamura C, et al.
Drug Metab Pharmacokinet
. 2011 Jan;
26(3):288-94.
PMID: 21273732
The cynomolgus monkey is an animal species widely used to study drug metabolism because of its evolutionary closeness to humans. However, drug-metabolizing enzyme activities have not been compared in various...
10.
Nakanishi Y, Matsushita A, Matsuno K, Iwasaki K, Utoh M, Nakamura C, et al.
Drug Metab Pharmacokinet
. 2010 Jul;
25(3):290-7.
PMID: 20610888
The cynomolgus monkey is used to study drug metabolism because of its evolutionary closeness to humans. Despite their importance, regional distribution of cytochrome P450 (CYP) enzymes including CYP3As in the...