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Yassene Mohammed

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Articles 66
Citations 543
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Recent Articles
11.
Gan J, de Vries J, Akkermans J, Mohammed Y, Tjokrodirijo R, de Ru A, et al.
ACS Chem Biol . 2023 Aug; 18(9):2003-2013. PMID: 37642399
Ubiquitin thioesterase OTUB2, a cysteine protease from the ovarian tumor (OTU) deubiquitinase superfamily, is often overexpressed during tumor progression and metastasis. Development of OTUB2 inhibitors is therefore believed to be...
12.
Zhou E, Ge X, Nakashima H, Li R, van der Zande H, Liu C, et al.
EMBO Mol Med . 2023 Jun; 15(8):e16845. PMID: 37357756
Liver X receptor (LXR) agonism has theoretical potential for treating NAFLD/NASH, but synthetic agonists induce hyperlipidemia in preclinical models. Desmosterol, which is converted by Δ24-dehydrocholesterol reductase (DHCR24) into cholesterol, is...
13.
Mohammed Y, Goodlett D, Borchers C
Methods Mol Biol . 2023 Feb; 2628:557-577. PMID: 36781806
In targeted proteomics experiments, selecting the appropriate proteotypic peptides as surrogate for the target protein is a crucial pre-acquisition step. This step is largely a bioinformatics exercise that involves integrating...
14.
Mohammed Y, Goodlett D, Borchers C
Methods Mol Biol . 2023 Feb; 2628:439-473. PMID: 36781801
Preclinical and clinical trials require rapid, precise, and multiplexed analytical methods to characterize the complex samples and to allow high-throughput biomarker monitoring with low consumption of sample material. Targeted proteomics...
15.
Ghorasaini M, Tsezou K, Verhoeven A, Mohammed Y, Vlachoyiannopoulos P, Mikros E, et al.
Metabolites . 2022 Nov; 12(11). PMID: 36355113
The lipid composition of lipoprotein particles is determinative of their respective formation and function. In turn, the combination and correlation of nuclear magnetic resonance (NMR)-based lipoprotein measurements with mass spectrometry...
16.
Richard V, Gaither C, Popp R, Chaplygina D, Brzhozovskiy A, Kononikhin A, et al.
Mol Cell Proteomics . 2022 Aug; 21(10):100277. PMID: 35931319
The recent surge of coronavirus disease 2019 (COVID-19) hospitalizations severely challenges healthcare systems around the globe and has increased the demand for reliable tests predictive of disease severity and mortality....
17.
Rocheleau G, Lee T, Mohammed Y, Goodlett D, Burns K, Cheng M, et al.
Crit Care Med . 2022 May; 50(9):1306-1317. PMID: 35607951
Objectives: To determine whether angiotensin receptor blockers (ARBs) or angiotensin-converting enzyme (ACE) inhibitors are associated with improved outcomes in hospitalized patients with COVID-19 according to sex and to report sex-related...
18.
Dapic I, Uwugiaren N, Kers J, Mohammed Y, Goodlett D, Corthals G
Molecules . 2022 Feb; 27(3). PMID: 35164409
The application of proteomics to fresh frozen (FF) and formalin-fixed paraffin-embedded (FFPE) human tissues is an important development spurred on by requests from stakeholder groups in clinical fields. One objective...
19.
Mohammed Y, Goodlett D, Cheng M, Vinh D, Lee T, McGeer A, et al.
J Proteome Res . 2022 Feb; 21(4):975-992. PMID: 35143212
The host response to COVID-19 pathophysiology over the first few days of infection remains largely unclear, especially the mechanisms in the blood compartment. We report on a longitudinal proteomic analysis...
20.
Smits W, Mohammed Y, de Ru A, Cordo V, Friggen A, Van Veelen P, et al.
mSphere . 2022 Jan; 7(1):e0091121. PMID: 34986318
Phosphorylation is a posttranslational modification that can affect both housekeeping functions and virulence characteristics in bacterial pathogens. In the Gram-positive enteropathogen Clostridioides difficile, the extent and nature of phosphorylation events...