Yasien Sayed
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Explore the profile of Yasien Sayed including associated specialties, affiliations and a list of published articles.
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Articles
62
Citations
258
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Recent Articles
1.
Venkatachalam S, Krishnan S, Pandian R, Sayed Y, Gromiha M
Proteins
. 2025 Mar;
PMID: 40026243
In recent years, Human Immunodeficiency Virus (HIV) remains a significant global health challenge, with millions affected worldwide, particularly in Africa and sub-Saharan regions. Despite advances in antiretroviral therapies, the genetic...
2.
Sookai S, Akerman M, Faerch M, Sayed Y, Munro O
Eur J Med Chem
. 2025 Feb;
287:117330.
PMID: 39904146
Topoisomerase IIα (Top II) is a critical enzyme that resolves DNA topology during transcription and replication. Inhibitors of Top II are used as anticancer agents and are classified as interfacial...
3.
Mokoto T, Lemmerer A, Sayed Y, Smith M
Acta Crystallogr E Crystallogr Commun
. 2024 Dec;
80(Pt 11):1206-1209.
PMID: 39712149
Lopinavir is a potent protease inhibitor that is used as a first-line pharmaceutical drug for the treatment of HIV. The multi-component solvated Lopinavir crystal, systematic name (2)--[(2,4,5)-5-[2-(2,6-di-methyl-phen-oxy)acetamido]-4-hy-droxy-1,6-di-phenyl-hexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide-ethane-1,2-diol-water (8/3/7) 8CHNO·3CHO·7HO, was...
4.
Venkatachalam S, Krishnan S, Sayed Y, Gromiha M
Methods Mol Biol
. 2024 Nov;
2867:185-200.
PMID: 39576582
Human immunodeficiency virus (HIV) targets the host immune system causing acquired immunodeficiency syndrome (AIDS). Although significant advancements have been made on investigating HIV and related infections, eradicating the virus from...
5.
Mokhantso T, Sherry D, Worth R, Pandian R, Achilonu I, Sayed Y
J Mol Graph Model
. 2024 Sep;
133:108850.
PMID: 39226791
HIV-1 protease (PR) enzyme is a viable antiretroviral drug target due to its crucial role in HIV maturation. Over many decades, the HIV-1 PR enzyme has exhibited mutations brought on...
6.
Sherry D, Sayed Y
Proteins
. 2024 Aug;
92(12):1398-1412.
PMID: 39109919
The HIV-1 protease is critical for the process of viral maturation and as such, it is one of the most well characterized proteins in the Protein Data Bank. There is...
7.
Soobben M, Sayed Y, Achilonu I
Comput Biol Chem
. 2024 Jun;
112:108138.
PMID: 38943725
The bioinformatic analysis of cannabinoid receptors (CBRs) CB and CB reveals a detailed picture of their structure, evolution, and physiological significance within the endocannabinoid system (ECS). The study highlights the...
8.
Sankaran S, Krishnan S, Sayed Y, Gromiha M
Curr Res Struct Biol
. 2024 Mar;
7:100132.
PMID: 38435053
AIDS is one of the deadliest diseases in the history of humankind caused by HIV. Despite the technological development, curtailing the viral infection inside human host still remains a challenge....
9.
Jeje O, Pandian R, Sayed Y, Achilonu I
Int J Biol Macromol
. 2023 Aug;
250:126066.
PMID: 37544558
Nicotinate nucleotide adenylyltransferase (NNAT) has been a significant research focus on druggable targets, given its indispensability in the biosynthesis of NAD, which is crucial to the survival of bacterial pathogens....
10.
Sheik Ismail Z, Worth R, Mosebi S, Sayed Y
Protein J
. 2023 Jul;
42(5):490-501.
PMID: 37421557
HIV-1 protease is essential for the production of mature, infectious virions and is a major target in antiretroviral therapy. We successfully purified a HIV-1 subtype C variant, L38↑N↑L, containing an...