Yashi Ahmed
Overview
Explore the profile of Yashi Ahmed including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
650
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Recent Articles
1.
Shen C, Lu W, Merugu S, Bharti A, Afify S, Schnitkey L, et al.
Cell Rep
. 2025 Feb;
44(2):115274.
PMID: 39908140
The mechanism by which Wnt signaling, an essential pathway controlling development and disease, stabilizes β-catenin has been a subject of debate over the last four decades. Casein kinase 1α (CK1α)...
2.
Hartmann H, Siddiqui G, Bryant J, Robbins D, Weiss V, Ahmed Y, et al.
Bioessays
. 2024 Nov;
47(2):e2400110.
PMID: 39520379
Signaling through the Wnt/β-catenin pathway is relayed through three multiprotein complexes: (1) the membrane-associated signalosome, which includes the activated Wnt receptors, (2) the cytoplasmic destruction complex that regulates turnover of...
3.
Ando T, Takazawa I, Spencer Z, Ito R, Tomimori Y, Mikulski Z, et al.
Cells
. 2024 Jun;
13(11.
PMID: 38891118
Crohn's disease is a chronic, debilitating, inflammatory bowel disease. Here, we report a critical role of phospholipase C-β3 (PLC-β3) in intestinal homeostasis. In PLC-β3-deficient mice, exposure to oral dextran sodium...
4.
Ng V, Spencer Z, Neitzel L, Nayak A, Loberg M, Shen C, et al.
Nat Commun
. 2023 Oct;
14(1):6173.
PMID: 37798301
The relative abundance of Wnt receptors plays a crucial role in controlling Wnt signaling in tissue homeostasis and human disease. While the ubiquitin ligases that ubiquitylate Wnt receptors are well-characterized,...
5.
The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6
Spencer Z, Ng V, Benchabane H, Siddiqui G, Duwadi D, Maines B, et al.
Nat Commun
. 2023 Oct;
14(1):6174.
PMID: 37798281
The control of Wnt receptor abundance is critical for animal development and to prevent tumorigenesis, but the mechanisms that mediate receptor stabilization remain uncertain. We demonstrate that stabilization of the...
6.
Kassel S, Hanson A, Benchabane H, Saito-Diaz K, Cabel C, Goldsmith L, et al.
Sci Signal
. 2023 Feb;
16(771):eabn8372.
PMID: 36749823
The Wnt-β-catenin signal transduction pathway is essential for embryonic development and adult tissue homeostasis. Wnt signaling converts TCF from a transcriptional repressor to an activator in a process facilitated by...
7.
Cantoria M, Alizadeh E, Ravi J, Varghese R, Bunnag N, Pond K, et al.
Proc Natl Acad Sci U S A
. 2023 Jan;
120(2):e2208787120.
PMID: 36598937
Wnt ligands are considered classical morphogens, for which the strength of the cellular response is proportional to the concentration of the ligand. Herein, we show an emergent property of bistability...
8.
Shen C, Nayak A, Neitzel L, Yang F, Li B, Williams C, et al.
J Biol Chem
. 2022 Jul;
298(8):102227.
PMID: 35780831
The Cullin-RING ligase 4 E3 ubiquitin ligase component Cereblon (CRBN) is a well-established target for a class of small molecules termed immunomodulatory drugs (IMiDs). These drugs drive CRBN to modulate...
9.
Shen C, Nayak A, Neitzel L, Adams A, Silver-Isenstadt M, Sawyer L, et al.
Nat Commun
. 2021 Sep;
12(1):5263.
PMID: 34489457
Immunomodulatory drugs (IMiDs) are important for the treatment of multiple myeloma and myelodysplastic syndrome. Binding of IMiDs to Cereblon (CRBN), the substrate receptor of the CRL4 E3 ubiquitin ligase, induces...
10.
Shen C, Nayak A, Melendez R, Wynn D, Jackson J, Lee E, et al.
Int J Mol Sci
. 2020 Aug;
21(16).
PMID: 32824859
Wnt signaling regulates numerous cellular processes during embryonic development and adult tissue homeostasis. Underscoring this physiological importance, deregulation of the Wnt signaling pathway is associated with many disease states, including...