Yaling Yi
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Explore the profile of Yaling Yi including associated specialties, affiliations and a list of published articles.
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26
Citations
937
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Recent Articles
1.
Yuan F, Sun X, Park S, Tang Y, Feng Z, Ebadi M, et al.
Hum Gene Ther
. 2025 Jan;
PMID: 39791230
Cystic fibrosis (CF) is caused by mutations in the (). While gene therapy holds promise as a cure, the cell-type-specific heterogeneity of expression in the lung presents significant challenges. Current...
2.
Rotti P, Yi Y, Gasser G, Yuan F, Sun X, Apak-Evans I, et al.
iScience
. 2024 Dec;
27(12):111393.
PMID: 39687022
Inflammation, acinar atrophy, and ductal hyperplasia drive pancreatic remodeling in newborn cystic fibrosis (CF) ferrets lacking a functional cystic fibrosis conductance regulator (CFTR) channel. These changes are associated with a...
3.
Evans I, Sun X, Liang B, Vegter A, Guo L, Lynch T, et al.
JCI Insight
. 2024 Apr;
9(8.
PMID: 38646935
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) gene, with F508del being the most prevalent mutation. The combination of CFTR modulators (potentiator and correctors)...
4.
Chan C, Granados A, Moheet A, Singh S, Vigers T, Arbelaez A, et al.
J Clin Transl Endocrinol
. 2023 Jan;
30:100311.
PMID: 36620757
Background: Diabetes is prevalent among people with CF (PwCF) and associated with worse clinical outcomes. CFTR modulators are highly effective in improving the disease course of CF. However, the effects...
5.
Uc A, Strandvik B, Yao J, Liu X, Yi Y, Sun X, et al.
Clin Sci (Lond)
. 2022 Nov;
136(24):1773-1791.
PMID: 36416119
Persons with cystic fibrosis (CF) exhibit a unique alteration of fatty acid composition, marked especially among polyunsaturates by relative deficiency of linoleic acid and excess of Mead acid. Relative deficiency...
6.
OMalley Y, Coleman M, Sun X, Lei J, Yao J, Pulliam C, et al.
Adv Redox Res
. 2022 Jul;
5.
PMID: 35903252
Cystic fibrosis-related diabetes (CFRD) is one the most common comorbidities in cystic fibrosis (CF). Pancreatic oxidative stress has been postulated in the pathogenesis of CFRD, but no studies have been...
7.
He N, Liu X, Vegter A, Evans T, Gray J, Guo J, et al.
JCI Insight
. 2022 Feb;
7(5).
PMID: 35104244
Alpha-1 antitrypsin deficiency (AATD) is the most common genetic cause and risk factor for chronic obstructive pulmonary disease, but the field lacks a large-animal model that allows for longitudinal assessment...
8.
Yi Y, Sun X, Liang B, He N, Gibson-Corley K, Norris A, et al.
Pancreatology
. 2021 May;
21(5):839-847.
PMID: 33994067
Background: /Objectives: The pathogenesis of hyperglycemia during acute pancreatitis (AP) remains unknown due to inaccessibility of human tissues and lack of animal models. We aimed to develop an animal model...
9.
Sun X, Yi Y, Yan Z, Rosen B, Liang B, Winter M, et al.
Sci Transl Med
. 2019 Mar;
11(485).
PMID: 30918114
Cystic fibrosis (CF) is a multiorgan disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (). In patients with CF, abnormalities initiate in several organs before birth. However,...
10.
Tyler S, Rotti P, Sun X, Yi Y, Xie W, Winter M, et al.
Cell Rep
. 2019 Feb;
26(7):1951-1964.e8.
PMID: 30759402
Toolsets available for in-depth analysis of scRNA-seq datasets by biologists with little informatics experience is limited. Here, we describe an informatics tool (PyMINEr) that fully automates cell type identification, cell...