Xiongfong Chen
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Explore the profile of Xiongfong Chen including associated specialties, affiliations and a list of published articles.
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28
Citations
520
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Recent Articles
1.
Bromodomain protein BRD4 directs mitotic cell division of mouse fibroblasts by inhibiting DNA damage
Wu T, Hou H, Dey A, Bachu M, Chen X, Wisniewski J, et al.
iScience
. 2024 Jul;
27(7):109797.
PMID: 38993671
Bromodomain protein BRD4 binds to acetylated histones to regulate transcription. BRD4 also drives cancer cell proliferation. However, the role of BRD4 in normal cell growth has remained unclear. Here, we...
2.
Wu T, Hou H, Dey A, Bachu M, Chen X, Wisniewski J, et al.
bioRxiv
. 2023 Aug;
PMID: 37546888
BRD4 binds to acetylated histones to regulate transcription and drive cancer cell proliferation. However, the role of BRD4 in normal cell growth remains to be elucidated. Here we investigated the...
3.
Talsania K, Shen T, Chen X, Jaeger E, Li Z, Chen Z, et al.
Genome Biol
. 2022 Dec;
23(1):255.
PMID: 36514120
Background: The cancer genome is commonly altered with thousands of structural rearrangements including insertions, deletions, translocation, inversions, duplications, and copy number variations. Thus, structural variant (SV) characterization plays a paramount...
4.
Hartford C, Shrestha R, Pongor L, Zhao Y, Chen X, Fromont C, et al.
Mol Cell Biol
. 2022 Nov;
42(12):e0028922.
PMID: 36342127
is a p53-induced lncRNA that suppresses basal p53 levels. Here, we investigated upon p53 activation in liver cancer cells, where it is expressed at significantly higher levels than other cell...
5.
Shinzawa M, Moseman E, Gossa S, Mano Y, Bhattacharya A, Guinter T, et al.
Nat Immunol
. 2022 May;
23(5):731-742.
PMID: 35523960
T cell specificity and function are linked during development, as MHC-II-specific TCR signals generate CD4 helper T cells and MHC-I-specific TCR signals generate CD8 cytotoxic T cells, but the basis...
6.
Zhao Y, Fang L, Shen T, Choudhari S, Talsania K, Chen X, et al.
Sci Data
. 2021 Nov;
8(1):296.
PMID: 34753956
With the rapid advancement of sequencing technologies, next generation sequencing (NGS) analysis has been widely applied in cancer genomics research. More recently, NGS has been adopted in clinical oncology to...
7.
Yu L, Majerciak V, Xue X, Uberoi A, Lobanov A, Chen X, et al.
PLoS Pathog
. 2021 Aug;
17(8):e1009812.
PMID: 34343212
MmuPV1 is a useful model for studying papillomavirus-induced tumorigenesis. We used RNA-seq to look for chimeric RNAs that map to both MmuPV1 and host genomes. In tumor tissues, a higher...
8.
Ricketts C, Vocke C, Lang M, Chen X, Zhao Y, Tran B, et al.
J Med Genet
. 2020 Oct;
59(1):18-22.
PMID: 33067352
Von Hippel-Lindau (VHL) disease is an autosomal dominant hereditary tumour susceptibility disease caused by germline pathogenic variation of the tumour suppressor gene. Affected individuals are at risk of developing multiple...
9.
Wang C, Qi X, Zhou X, Sun J, Cai D, Lu G, et al.
FASEB J
. 2020 Jul;
34(9):12726-12738.
PMID: 32713114
The proto-oncogene ets1 is highly expressed in the pre-migratory and migratory neural crest (NC), and has been implicated in the delamination and migration of the NC cells. To identify the...
10.
Avula L, Rudloff M, El-Behaedi S, Arons D, Albalawy R, Chen X, et al.
Mol Cancer Res
. 2019 Nov;
18(2):229-239.
PMID: 31676721
Over 90% of pancreatic ductal adenocarcinomas (PDAC) express mesothelin (MSLN). Overexpression or knockdown of MSLN has been implicated in PDAC aggressiveness. This activity has been ascribed to MSLN-induced activation of...