Xinlai Cheng
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Explore the profile of Xinlai Cheng including associated specialties, affiliations and a list of published articles.
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Articles
48
Citations
588
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Recent Articles
1.
Altinbay M, Wang J, Chen J, Schafer D, Sprang M, Blagojevic B, et al.
Nucleic Acids Res
. 2024 Sep;
52(19):11587-11601.
PMID: 39315698
Epigenetic aberration is one of the major driving factors in human cancer, often leading to acquired resistance to chemotherapies. Various small molecule epigenetic modulators have been reported. Nonetheless, outcomes from...
2.
Hasselbeck S, Cheng X
Pharmaceuticals (Basel)
. 2024 Jan;
17(1).
PMID: 38256875
In the rapidly evolving landscape of genetic engineering, the advent of CRISPR-Cas technologies has catalyzed a paradigm shift, empowering scientists to manipulate the genetic code with unprecedented accuracy and efficiency....
3.
Kang H, Hasselbeck S, Taskova K, Wang N, Oosten L, Mrowka R, et al.
Eur J Med Chem
. 2023 May;
257:115513.
PMID: 37253308
The identification of small molecules capable of replacing transcription factors has been a longstanding challenge in the generation of human chemically induced pluripotent stem cells (iPSCs). Recent studies have shown...
4.
Schaefer D, Cheng X
Pharmaceuticals (Basel)
. 2023 May;
16(5).
PMID: 37242447
In spite of the increasing number of biologics license applications, the development of covalent inhibitors is still a growing field within drug discovery. The successful approval of some covalent protein...
5.
Shoaib A, Waqas M, Elabasy A, Cheng X, Zhang Q, Shi Z
RSC Adv
. 2022 May;
8(28):15687-15697.
PMID: 35539448
Colloidal delivery systems have been widely used as carriers for controlled delivery of pesticides to improve the efficacy and photostability of natural and semi-synthetic pesticides. In this study, we have...
6.
Zhou J, Dabiri Y, Gama-Brambila R, Ghafoory S, Altinbay M, Mehrabi A, et al.
J Cell Biol
. 2021 Dec;
221(1).
PMID: 34860252
Transforming growth factor β (TGF-β) signaling plays a fundamental role in metazoan development and tissue homeostasis. However, the molecular mechanisms concerning the ubiquitin-related dynamic regulation of TGF-β signaling are not...
7.
Gama-Brambila R, Chen J, Dabiri Y, Tascher G, Nemec V, Munch C, et al.
JACS Au
. 2021 Sep;
1(6):777-785.
PMID: 34467332
The discovery of clustered regularly interspaced short palindromic repeats and their associated proteins (Cas) has revolutionized the field of genome and epigenome editing. A number of new methods have been...
8.
Gama-Brambila R, Chen J, Zhou J, Tascher G, Munch C, Cheng X
Cell Chem Biol
. 2021 May;
28(11):1616-1627.e8.
PMID: 34048672
The proteolysis-targeting chimeras (PROTACs) are a new technology to degrade target proteins. However, their clinical application is limited currently by lack of chemical binders to target proteins. For instance, it...
9.
Ma D, Chen S, Wang H, Wei J, Wu H, Gao H, et al.
Front Oncol
. 2021 May;
11:653061.
PMID: 33996574
Pancreatic cancer is a common malignant tumor with a high incidence and mortality rate. The prognosis of patients with pancreatic cancer is considerably poor due to the lack of effective...
10.
Theobald J, Ghanem A, Wallisch P, Banaeiyan A, Andrade-Navarro M, Taskova K, et al.
ACS Biomater Sci Eng
. 2021 Jan;
4(1):78-89.
PMID: 33418680
Advances in organ-on-chip technologies for the application in in vitro drug development provide an attractive alternative approach to replace ethically controversial animal testing and to establish a basis for accelerated...