Xiaotian Kong
Overview
Explore the profile of Xiaotian Kong including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
170
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0
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Recent Articles
1.
Zhao Y, Zhang Z, Kong X, Wang K, Wang Y, Jia J, et al.
Chem Biol Drug Des
. 2024 Aug;
104(2):e14607.
PMID: 39179521
The process of developing new drugs is widely acknowledged as being time-intensive and requiring substantial financial investment. Despite ongoing efforts to reduce time and expenses in drug development, ensuring medication...
2.
Kong X, Han L, Yang L, Shi Z, Lang J, Ye M, et al.
Heliyon
. 2024 Aug;
10(14):e34846.
PMID: 39148993
. P. Y. Li represents a significant asset within traditional Chinese medicinal flora, though it confronts the challenge of germplasm deterioration during its cultivation phase. This study aimed to discern...
3.
Tao L, Zhou T, Wu Z, Hu F, Yang S, Kong X, et al.
J Chem Inf Model
. 2024 Apr;
64(8):3548-3557.
PMID: 38587997
Protein-DNA interactions are pivotal to various cellular processes. Precise identification of the hotspot residues for protein-DNA interactions holds great significance for revealing the intricate mechanisms in protein-DNA recognition and for...
4.
Liu Y, Yu K, Kong X, Zhang K, Wang L, Zhang N, et al.
Sci Adv
. 2023 Aug;
9(33):eadg7112.
PMID: 37595040
FOXA1, a transcription factor involved in epigenetic reprogramming, is crucial for breast cancer progression. However, the mechanisms by which FOXA1 achieves its oncogenic functions remain elusive. Here, we demonstrate that...
5.
Kong X, Xing E, Wu S, Zhuang T, Li P, Li C, et al.
Protein Sci
. 2022 Nov;
31(12):e4499.
PMID: 36335585
As a key regulator for hormone activity, human aldo-keto reductase family 1 member C3 (AKR1C3) plays crucial roles in the occurrence of various hormone-dependent or independent malignancies. It is a...
6.
Xing E, Surendranathan N, Kong X, Cyberski N, Garcia J, Cheng X, et al.
ACS Pharmacol Transl Sci
. 2021 Oct;
4(5):1628-1638.
PMID: 34661079
The bromodomain and extra-terminal (BET) domain family of proteins, which include its prototypical member Brd4, is implicated in a variety of cancers and viral infections due to their interaction with...
7.
Kong X, Xing E, Zhuang T, Li P, Cheng X
J Chem Inf Model
. 2021 Jun;
61(7):3477-3494.
PMID: 34165949
An androgen receptor (AR) is an intensively studied treatment target for castration-resistant prostate cancer that is irresponsive to conventional antiandrogen therapeutics. Binding function 3 (BF3) inhibitors with alternative modes of...
8.
Gorecki L, Gerlits O, Kong X, Cheng X, Blumenthal D, Taylor P, et al.
J Biol Chem
. 2020 May;
295(19):6784.
PMID: 32385098
No abstract available.
9.
Gorecki L, Gerlits O, Kong X, Cheng X, Blumenthal D, Taylor P, et al.
J Biol Chem
. 2020 Feb;
295(13):4079-4092.
PMID: 32019865
Organophosphate (OP) intoxications from nerve agent and OP pesticide exposures are managed with pyridinium aldoxime-based therapies whose success rates are currently limited. The pyridinium cation hampers uptake of OPs into...
10.
Kong X, Pan P, Sun H, Xia H, Wang X, Li Y, et al.
J Med Chem
. 2019 Aug;
62(24):10927-10954.
PMID: 31419130
As a receptor tyrosine kinase of insulin receptor (IR) subfamily, anaplastic lymphoma kinase (ALK) has been validated to play important roles in various cancers, especially anaplastic large cell lymphoma (ALCL),...