Xiaorui Yao
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Explore the profile of Xiaorui Yao including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
1536
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Recent Articles
11.
Yao X, Lu J, Liu Z, Ran D, Huang Y
Water Sci Technol
. 2013 May;
67(10):2342-9.
PMID: 23676408
Domestic sewage discharged into lakes brings great pressure to the ecological environment. This study selected sediment from an inland lake as a research object to evaluate pollution of the environment....
12.
Lin H, Chen D, Shen Z, Zhu L, Ouyang X, Vongs A, et al.
PLoS One
. 2013 Jan;
8(1):e54480.
PMID: 23336002
Diacylglycerol acyltransferase-1 (DGAT1) is a potential therapeutic target for treatment of obesity and related metabolic diseases. However, the degree of DGAT1 inhibition required for metabolic benefits is unclear. Here we...
13.
Lin H, Frassetto A, Kowalik Jr E, Nawrocki A, Lu M, Kosinski J, et al.
PLoS One
. 2012 Apr;
7(4):e35240.
PMID: 22506074
Short-chain fatty acids (SCFAs), primarily acetate, propionate, and butyrate, are metabolites formed by gut microbiota from complex dietary carbohydrates. Butyrate and acetate were reported to protect against diet-induced obesity without...
14.
Hawes B, Oneill K, Yao X, Crona J, Davis Jr H, Graziano M, et al.
Mol Pharmacol
. 2006 Sep;
71(1):19-29.
PMID: 17005902
Ezetimibe is the first in class 2-azetidinone that decreases plasma cholesterol by blocking intestinal cholesterol absorption. Ezetimibe effectively reduces plasma cholesterol in several species including human, monkey, dog, hamster, rat,...
15.
Iyer S, Yao X, Crona J, Hoos L, Tetzloff G, Davis Jr H, et al.
Biochim Biophys Acta
. 2005 Mar;
1722(3):282-92.
PMID: 15777641
The exact mechanistic pathway of cholesterol absorption in the jejunum of the small intestines is a poorly understood process. Recently, a relatively novel gene, Niemann-Pick C1 Like 1 (NPC1L1), was...
16.
Davis Jr H, Zhu L, Hoos L, Tetzloff G, Maguire M, Liu J, et al.
J Biol Chem
. 2004 Jun;
279(32):33586-92.
PMID: 15173162
Niemann-Pick C1 Like 1 (NPC1L1) is a protein localized in jejunal enterocytes that is critical for intestinal cholesterol absorption. The uptake of intestinal phytosterols and cholesterol into absorptive enterocytes in...
17.
Altmann S, Davis Jr H, Zhu L, Yao X, Hoos L, Tetzloff G, et al.
Science
. 2004 Feb;
303(5661):1201-4.
PMID: 14976318
Dietary cholesterol consumption and intestinal cholesterol absorption contribute to plasma cholesterol levels, a risk factor for coronary heart disease. The molecular mechanism of sterol uptake from the lumen of the...
18.
Altmann S, Davis Jr H, Yao X, Laverty M, Compton D, Zhu L, et al.
Biochim Biophys Acta
. 2002 Mar;
1580(1):77-93.
PMID: 11923102
The molecular mechanisms of cholesterol absorption in the intestine are poorly understood. With the goal of defining candidate genes involved in these processes a fluorescence-activated cell sorter-based, retroviral-mediated expression cloning...