Scott W Altmann
Overview
Explore the profile of Scott W Altmann including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
11
Citations
1220
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Davis Jr H, Altmann S
Biochim Biophys Acta
. 2009 Mar;
1791(7):679-83.
PMID: 19272334
Niemann-Pick C1 Like 1 (NPC1L1) has been identified and characterized as an essential protein in the intestinal cholesterol absorption process. NPC1L1 localizes to the brush border membrane of absorptive enterocytes...
2.
Davis Jr H, Basso F, Hoos L, Tetzloff G, Lally S, Altmann S
Atheroscler Suppl
. 2008 Jul;
9(2):77-81.
PMID: 18585981
Ezetimibe is a selective cholesterol absorption inhibitor, which potently inhibits the uptake and absorption of biliary and dietary cholesterol from the small intestine without affecting the absorption of fat-soluble vitamins,...
3.
Davis Jr H, Hoos L, Tetzloff G, Maguire M, Zhu L, Graziano M, et al.
Arterioscler Thromb Vasc Biol
. 2007 Jan;
27(4):841-9.
PMID: 17218600
Objective: The objective of this study was to determine whether the deficiency of Niemann-Pick C1 Like 1 (Npc1l1) prevents atherosclerosis in apoE null mice. Methods And Results: Npc1l1(-/-)/apoE null-/- mice...
4.
Hawes B, Oneill K, Yao X, Crona J, Davis Jr H, Graziano M, et al.
Mol Pharmacol
. 2006 Sep;
71(1):19-29.
PMID: 17005902
Ezetimibe is the first in class 2-azetidinone that decreases plasma cholesterol by blocking intestinal cholesterol absorption. Ezetimibe effectively reduces plasma cholesterol in several species including human, monkey, dog, hamster, rat,...
5.
Zhu L, Altmann S
Anal Biochem
. 2005 Sep;
345(1):102-9.
PMID: 16139233
Fluorescence-based reverse transcription real-time quantitative polymerase chain reaction (RT-QPCR) is a highly sensitive method for the detection and quantitation of mRNA. To control and correct for sample variability, some common...
6.
Garcia-Calvo M, Lisnock J, Bull H, Hawes B, Burnett D, Braun M, et al.
Proc Natl Acad Sci U S A
. 2005 Jun;
102(23):8132-7.
PMID: 15928087
Ezetimibe is a potent inhibitor of cholesterol absorption that has been approved for the treatment of hypercholesterolemia, but its molecular target has been elusive. Using a genetic approach, we recently...
7.
Iyer S, Yao X, Crona J, Hoos L, Tetzloff G, Davis Jr H, et al.
Biochim Biophys Acta
. 2005 Mar;
1722(3):282-92.
PMID: 15777641
The exact mechanistic pathway of cholesterol absorption in the jejunum of the small intestines is a poorly understood process. Recently, a relatively novel gene, Niemann-Pick C1 Like 1 (NPC1L1), was...
8.
Davis Jr H, Zhu L, Hoos L, Tetzloff G, Maguire M, Liu J, et al.
J Biol Chem
. 2004 Jun;
279(32):33586-92.
PMID: 15173162
Niemann-Pick C1 Like 1 (NPC1L1) is a protein localized in jejunal enterocytes that is critical for intestinal cholesterol absorption. The uptake of intestinal phytosterols and cholesterol into absorptive enterocytes in...
9.
Altmann S, Davis Jr H, Zhu L, Yao X, Hoos L, Tetzloff G, et al.
Science
. 2004 Feb;
303(5661):1201-4.
PMID: 14976318
Dietary cholesterol consumption and intestinal cholesterol absorption contribute to plasma cholesterol levels, a risk factor for coronary heart disease. The molecular mechanism of sterol uptake from the lumen of the...
10.
Altmann S, Davis Jr H, Yao X, Laverty M, Compton D, Zhu L, et al.
Biochim Biophys Acta
. 2002 Mar;
1580(1):77-93.
PMID: 11923102
The molecular mechanisms of cholesterol absorption in the intestine are poorly understood. With the goal of defining candidate genes involved in these processes a fluorescence-activated cell sorter-based, retroviral-mediated expression cloning...