Xiaodun Li
Overview
Explore the profile of Xiaodun Li including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
19
Citations
718
Followers
0
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Recent Articles
1.
Stevenson L, Cairns L, Li X, Jammula S, Taylor H, Douglas R, et al.
Sci Rep
. 2024 Dec;
14(1):32121.
PMID: 39739112
The incidence of oesophageal adenocarcinoma (OAC) has risen six-fold in western countries over the last forty years but survival rates have only marginally improved. Hyperactivation of the PI3K-AKT-mTOR pathway is...
2.
Ng A, McClurg D, Wesley B, Zamani S, Black E, Miremadi A, et al.
Nat Commun
. 2024 May;
15(1):4533.
PMID: 38806493
No abstract available.
3.
Ng A, McClurg D, Wesley B, Zamani S, Black E, Miremadi A, et al.
Nat Commun
. 2024 May;
15(1):4074.
PMID: 38744814
Esophageal adenocarcinoma is a prominent example of cancer characterized by frequent amplifications in oncogenes. However, the mechanisms leading to amplicons that involve breakage-fusion-bridge cycles and extrachromosomal DNA are poorly understood....
4.
Abujudeh S, Zeki S, van Lanschot M, Pusung M, Weaver J, Li X, et al.
BMC Genomics
. 2022 Aug;
23(1):599.
PMID: 35978291
Background: Somatic copy number alterations (SCNAs) are an important class of genomic alteration in cancer. They are frequently observed in cancer samples, with studies showing that, on average, SCNAs affect...
5.
Hughes R, Elliott R, Li X, Munro A, Makda A, Carter R, et al.
ACS Chem Biol
. 2022 Jun;
17(7):1876-1889.
PMID: 35696676
Esophageal adenocarcinoma is of increasing global concern due to increasing incidence, a lack of effective treatments, and poor prognosis. Therapeutic target discovery and clinical trials have been hindered by the...
6.
Price S, Bhosle S, Goncalves E, Li X, McClurg D, Barthorpe S, et al.
Sci Rep
. 2022 Apr;
12(1):5571.
PMID: 35368031
Organoid cell culture methodologies are enabling the generation of cell models from healthy and diseased tissue. Patient-derived cancer organoids that recapitulate the genetic and histopathological diversity of patient tumours are...
7.
Masque-Soler N, Gehrung M, Kosmidou C, Li X, Diwan I, Rafferty C, et al.
EBioMedicine
. 2022 Jan;
76:103814.
PMID: 35051729
Background: Non-endoscopic cell collection devices combined with biomarkers can detect Barrett's intestinal metaplasia and early oesophageal cancer. However, assays performed on multi-cellular samples lose information about the cell source of...
8.
Scott S, Li X, Jammula S, Devonshire G, Lindon C, Fitzgerald R, et al.
Cell Death Differ
. 2021 Mar;
28(7):2179-2193.
PMID: 33649470
Polyploidy is present in many cancer types and is increasingly recognized as an important factor in promoting chromosomal instability, genome evolution, and heterogeneity in cancer cells. However, the mechanisms that...
9.
Ceder S, Eriksson S, Cheteh E, Dawar S, Corrales Benitez M, Bykov V, et al.
EMBO Mol Med
. 2020 Dec;
13(2):e10852.
PMID: 33314700
The tumor suppressor gene TP53 is the most frequently mutated gene in cancer. The compound APR-246 (PRIMA-1Met/Eprenetapopt) is converted to methylene quinuclidinone (MQ) that targets mutant p53 protein and perturbs...
10.
Jammula S, Katz-Summercorn A, Li X, Linossi C, Smyth E, Killcoyne S, et al.
Gastroenterology
. 2020 Feb;
158(6):1682-1697.e1.
PMID: 32032585
Background & Aims: Esophageal adenocarcinomas (EACs) are heterogeneous and often preceded by Barrett's esophagus (BE). Many genomic changes have been associated with development of BE and EAC, but little is...