Matthew D Eldridge
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Explore the profile of Matthew D Eldridge including associated specialties, affiliations and a list of published articles.
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23
Citations
1583
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Recent Articles
1.
Sauer C, Hall J, Couturier D, Bradley T, Piskorz A, Griffiths J, et al.
Nat Commun
. 2023 Oct;
14(1):6505.
PMID: 37845213
High-grade serous ovarian carcinoma (HGSOC) is characterised by poor outcome and extreme chromosome instability (CIN). Therapies targeting centrosome amplification (CA), a key mediator of chromosome missegregation, may have significant clinical...
2.
Santonja A, Cooper W, Eldridge M, Edwards P, Morris J, Edwards A, et al.
EMBO Mol Med
. 2023 May;
15(6):e16505.
PMID: 37161793
Analysis of circulating tumor DNA (ctDNA) to monitor cancer dynamics and detect minimal residual disease has been an area of increasing interest. Multiple methods have been proposed but few studies...
3.
Ng A, Contino G, Killcoyne S, Devonshire G, Hsu R, Abbas S, et al.
Commun Biol
. 2022 Apr;
5(1):335.
PMID: 35396535
Oesophageal adenocarcinoma (OAC) provides an ideal case study to characterize large-scale rearrangements. Using whole genome short-read sequencing of 383 cases, for which 214 had matched whole transcriptomes, we observed structural...
4.
Howarth K, Mirza T, Cooke S, Chin S, Pole J, Turro E, et al.
Breast Cancer Res
. 2021 Jan;
23(1):3.
PMID: 33413557
Background: NRG1 gene fusions may be clinically actionable, since cancers carrying the fusion transcripts can be sensitive to tyrosine kinase inhibitors. The NRG1 gene encodes ligands for the HER2(ERBB2)-ERBB3 heterodimeric...
5.
Killcoyne S, Gregson E, Wedge D, Woodcock D, Eldridge M, De La Rue R, et al.
Nat Med
. 2020 Sep;
26(11):1726-1732.
PMID: 32895572
Recent studies show that aneuploidy and driver gene mutations precede cancer diagnosis by many years. We assess whether these genomic signals can be used for early detection and pre-emptive cancer...
6.
Schuijs M, Png S, Richard A, Tsyben A, Hamm G, Stockis J, et al.
Nat Immunol
. 2020 Aug;
21(9):998-1009.
PMID: 32747815
Metastasis constitutes the primary cause of cancer-related deaths, with the lung being a commonly affected organ. We found that activation of lung-resident group 2 innate lymphoid cells (ILC2s) orchestrated suppression...
7.
Perner J, Abbas S, Nowicki-Osuch K, Devonshire G, Eldridge M, Tavare S, et al.
Nat Commun
. 2020 Jun;
11(1):3166.
PMID: 32576827
Mutational processes acting on cancer genomes can be traced by investigating mutational signatures. Because high sequencing costs limit current studies to small numbers of good-quality samples, we propose a robust,...
8.
Jammula S, Katz-Summercorn A, Li X, Linossi C, Smyth E, Killcoyne S, et al.
Gastroenterology
. 2020 Feb;
158(6):1682-1697.e1.
PMID: 32032585
Background & Aims: Esophageal adenocarcinomas (EACs) are heterogeneous and often preceded by Barrett's esophagus (BE). Many genomic changes have been associated with development of BE and EAC, but little is...
9.
Noorani A, Li X, Goddard M, Crawte J, Alexandrov L, Secrier M, et al.
Nat Genet
. 2020 Jan;
52(1):74-83.
PMID: 31907488
The poor outcomes in esophageal adenocarcinoma (EAC) prompted us to interrogate the pattern and timing of metastatic spread. Whole-genome sequencing and phylogenetic analysis of 388 samples across 18 individuals with...
10.
Dokshin G, Davis G, Sawle A, Eldridge M, Nicholls P, Gourley T, et al.
Dev Cell
. 2019 Dec;
52(1):53-68.e6.
PMID: 31839538
GCNA proteins are expressed across eukarya in pluripotent cells and have conserved functions in fertility. GCNA homologs Spartan (DVC-1) and Wss1 resolve DNA-protein crosslinks (DPCs), including Topoisomerase-DNA adducts, during DNA...