Xian-Jun Qu
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Explore the profile of Xian-Jun Qu including associated specialties, affiliations and a list of published articles.
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79
Citations
872
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Recent Articles
1.
Guo Z, Wu X, Tan M, Liang W, Yang Y, Chu Z, et al.
J Adv Res
. 2025 Jan;
PMID: 39814224
Introduction: Dihydropyrimidine dehydrogenase (DPD) is a major determinant of cancer 5-fluorouracyl (5-FU) resistance via its direct degradation. However, the mechanisms of tumoral DPD upregulation have not been fully understood. Objectives:...
2.
Miao R, Zhan S, Cui S, Qu X
FASEB J
. 2022 Jul;
36(8):e22398.
PMID: 35792869
Conjugated bile acids (CBAs) play major roles in hepatic gene regulation via nuclear S1P-inhibited histone deacetylase (HDACs). Gut microbiota modifies bile acid pool to generate CBAs and then CBAs returned...
3.
Yang J, Miao R, Li Y, Pan T, Wu S, Qu X, et al.
Acta Pharmacol Sin
. 2022 Apr;
43(11):2967-2976.
PMID: 35365782
Atypical chemokine receptor 3 (ACKR3) has emerged as a key player in various biological processes. Its atypical "intercepting receptor" properties have established ACKR3 as the major regulator in the pathophysiological...
4.
Miao R, Zhan S, Hu X, Yuan W, Wu L, Cui S, et al.
Toxicol Lett
. 2021 Apr;
346:7-15.
PMID: 33811973
Our previous studies found that M10, a myricetin-3-O-β-d-lactose sodium salt, possessed higher effects of ameliorating ulcerative colitis (UC) than Myricetin in mice. Here, we aim to investigate whether the inhibition...
5.
Sun S, Hu X, Yu X, Zhang Y, Liu X, Liu Y, et al.
Br J Pharmacol
. 2021 Mar;
178(11):2351-2369.
PMID: 33645631
Background And Purpose: It is well known that microsatellite instability-high (MSI-H) is associated with 5-fluorouracil (5-FU) resistance in colorectal cancer. MSI-H is the phenotype of DNA mismatch repair deficiency (MMR-D),...
6.
Zhou X, Yang J, Qu X, Meng J, Miao R, Cui S
Front Pharmacol
. 2020 Oct;
11:557312.
PMID: 33041798
Background: M10 is a derivative of Myricetin by adding a hydrophilic glycosylation group. Our previous study revealed that M10 by oral administration prevented colitis-associated colonic cancer (CAC) through attenuating endoplasmic...
7.
Zhang Y, Cui S, Wan S, Wu S, Qu X
Acta Pharmacol Sin
. 2020 Jul;
42(3):460-469.
PMID: 32647340
Sphingosine-1-phosphate (S1P), the backbone of most sphingolipids, activating S1P receptors (S1PRs) and the downstream G protein signaling has been implicated in chemoresistance. In this study we investigated the role of...
8.
Zhang Y, Shi W, Wu S, Miao R, Sun S, Luo D, et al.
Oncogene
. 2020 Jun;
39(29):5214-5227.
PMID: 32546724
Aberrant sphingolipid metabolism has been implicated in chemoresistance, but the underlying mechanisms are still poorly understood. Herein we revealed a previously unrecognized mechanism of 5-fluorouracil (5-FU) resistance contributed by high...
9.
Zhang Y, Luo D, Wan S, Qu X
Pharmacol Res
. 2020 Jun;
159:104834.
PMID: 32473828
No abstract available.
10.
Zhang Y, Luo D, Wan S, Qu X
Pharmacol Res
. 2020 Feb;
155:104717.
PMID: 32088343
In this study, S1PR2 was reckoned as a brand-new GPCR target for designing inhibitors to reverse 5-FU resistance. Herein a series of pyrrolidine pyrazoles as the S1PR2 inhibitors were designed,...