Xiakun Chu
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Explore the profile of Xiakun Chu including associated specialties, affiliations and a list of published articles.
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38
Citations
402
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Recent Articles
1.
Luo Y, Yan Z, Chu X, Zhang Y, Qiu Y, Li H
Commun Biol
. 2025 Feb;
8(1):221.
PMID: 39939814
Histone deacetylase 8 (HDAC8) is a well-known epigenetic regulator for cancer therapy. However, developing targeted inhibitors for HDAC8 is challenging due to a limited understanding of its structural dynamics, which...
2.
Wang C, Ma C, Xu Y, Chang S, Wu H, Yan C, et al.
Nat Commun
. 2025 Jan;
16(1):917.
PMID: 39843418
The multi-enzyme pyruvate dehydrogenase complex (PDHc) links glycolysis to the citric acid cycle and plays vital roles in metabolism, energy production, and cellular signaling. Although all components have been individually...
3.
Xu C, Chu X
Biochemistry
. 2024 Nov;
63(24):3261-3272.
PMID: 39602187
Engrailed homeodomain (EngHD), a highly charged transcription factor regulating over 200 genes, is a fast-folding protein. Recent studies have shown that the abundant charged residues in EngHD not only facilitate...
4.
Zhu T, Li C, Chu X
J Phys Chem Lett
. 2024 Nov;
15(45):11428-11436.
PMID: 39508790
Enhancers regulate gene expression by forming contacts with distant promoters. Phase-separated condensates or clusters formed by transcription factors (TFs) and cofactors are thought to facilitate these enhancer-promoter (E-P) interactions. Using...
5.
Xu S, Huo C, Chu X
J Chem Inf Model
. 2024 Sep;
64(19):7576-7589.
PMID: 39269430
The accumulation of polyethylene terephthalate (PET), a widely used polyester plastic in packaging and textiles, has led to a global environmental crisis. Biodegradation presents a promising strategy for PET recycling,...
6.
Zhang G, Chu X
J Chem Phys
. 2024 Sep;
161(9).
PMID: 39225535
Intrinsically disordered proteins (IDPs) are prevalent participants in liquid-liquid phase separation due to their inherent potential for promoting multivalent binding. Understanding the underlying mechanisms of phase separation is challenging, as...
7.
He Y, Wang S, Wen J, Feng N, Ma R, Zhang H, et al.
Nano Lett
. 2024 Jul;
24(31):9750-9759.
PMID: 39052067
(Ago)-based bioassays are popular due to their programmability and directional cleavage capabilities. However, the relatively compact protein structure of Ago limits its cleavage activity (even at the optimal temperature), thus...
8.
Zhu Q, Geng D, Li J, Zhang J, Sun H, Fan Z, et al.
Adv Sci (Weinh)
. 2024 Apr;
11(24):e2308522.
PMID: 38582526
Glycans are complex biomolecules that encode rich information and regulate various biological processes, such as fertilization, host-pathogen binding, and immune recognition, through interactions with glycan-binding proteins. A key driving force...
9.
Chu X, Wang J
Biophys Rev (Melville)
. 2024 Mar;
3(4):041402.
PMID: 38505520
The cell fate decision-making process, which provides the capability of a cell transition to a new cell type, involves the reorganizations of 3D genome structures. Currently, the high temporal resolution...
10.
Chu X, Wang J
Open Biol
. 2023 Oct;
13(11):230175.
PMID: 37907089
Cell cycle is known to be regulated by the underlying gene network. Chromosomes, which serve as the scaffold for gene expressions, undergo significant structural reorganizations during mitosis. Understanding the mechanism...