Wouter Vervecken
Overview
Explore the profile of Wouter Vervecken including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
1029
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0
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Recent Articles
1.
Costain W, Haqqani A, Hussack G, van Faassen H, Lessard E, Ling B, et al.
Fluids Barriers CNS
. 2025 Jan;
22(1):7.
PMID: 39810248
Background: Iduronate-2-sulfatase (IDS) deficiency (MPS II; Hunter syndrome) is a disorder that exhibits peripheral and CNS pathology. The blood brain barrier (BBB) prevents systemic enzyme replacement therapy (ERT) from alleviating...
2.
Cuskin F, Lowe E, Temple M, Zhu Y, Cameron E, Pudlo N, et al.
Nature
. 2015 Mar;
520(7547):388.
PMID: 25739504
No abstract available.
3.
Cuskin F, Lowe E, Temple M, Zhu Y, Cameron E, Pudlo N, et al.
Nature
. 2015 Jan;
517(7533):165-169.
PMID: 25567280
Yeasts, which have been a component of the human diet for at least 7,000 years, possess an elaborate cell wall α-mannan. The influence of yeast mannan on the ecology of...
4.
Tiels P, Baranova E, Piens K, De Visscher C, Pynaert G, Nerinckx W, et al.
Nat Biotechnol
. 2012 Nov;
30(12):1225-31.
PMID: 23159880
Lysosomal storage diseases are treated with human lysosomal enzymes produced in mammalian cells. Such enzyme therapeutics contain relatively low levels of mannose-6-phosphate, which is required to target them to the...
5.
De Pourcq K, Tiels P, Van Hecke A, Geysens S, Vervecken W, Callewaert N
PLoS One
. 2012 Jul;
7(6):e39976.
PMID: 22768188
Yarrowia lipolytica is a dimorphic yeast that efficiently secretes various heterologous proteins and is classified as "generally recognized as safe." Therefore, it is an attractive protein production host. However, yeasts...
6.
De Pourcq K, Vervecken W, Dewerte I, Valevska A, Van Hecke A, Callewaert N
Microb Cell Fact
. 2012 May;
11:53.
PMID: 22548968
Background: Protein-based therapeutics represent the fastest growing class of compounds in the pharmaceutical industry. This has created an increasing demand for powerful expression systems. Yeast systems are widely used, convenient...
7.
Jacobs P, Geysens S, Vervecken W, Contreras R, Callewaert N
Nat Protoc
. 2009 Jan;
4(1):58-70.
PMID: 19131957
Here we provide a protocol for engineering the N-glycosylation pathway of the yeast Pichia pastoris. The general strategy consists of the disruption of an endogenous glycosyltransferase gene (OCH1) and the...
8.
Contribution of galactofuranose to the virulence of the opportunistic pathogen Aspergillus fumigatus
Schmalhorst P, Krappmann S, Vervecken W, Rohde M, Muller M, Braus G, et al.
Eukaryot Cell
. 2008 Jun;
7(8):1268-77.
PMID: 18552284
The filamentous fungus Aspergillus fumigatus is responsible for a lethal disease called invasive aspergillosis that affects immunocompromised patients. This disease, like other human fungal diseases, is generally treated by compounds...
9.
Vervecken W, Callewaert N, Kaigorodov V, Geysens S, Contreras R
Methods Mol Biol
. 2007 Oct;
389:119-38.
PMID: 17951639
Glycosylation is an important issue in heterologous protein production for therapeutic applications. Glycoproteins produced in Pichia pastoris contain high mannose glycan structures that can hamper downstream processing, might be immunogenic,...
10.
Desmyter L, Fan Y, Praet M, Jaworski T, Vervecken W, de Hemptinne B, et al.
J Gastroenterol Hepatol
. 2007 Jul;
22(7):1148-54.
PMID: 17608861
Background: Non-invasive staging of human liver fibrosis is a desirable objective that remains under extensive evaluation. Animal model systems are often used for studying human liver disease and screening antifibrotic...