Roland Contreras
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Explore the profile of Roland Contreras including associated specialties, affiliations and a list of published articles.
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44
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1956
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Recent Articles
1.
Laukens B, Jacobs P, Geysens K, Martins J, De Wachter C, Ameloot P, et al.
Biotechnol Bioeng
. 2020 May;
117(8):2479-2488.
PMID: 32374435
The glycosylation pathways of several eukaryotic protein expression hosts are being engineered to enable the production of therapeutic glycoproteins with humanized application-customized glycan structures. In several expression hosts, this has...
2.
Jacobs P, Inan M, Festjens N, Haustraete J, Van Hecke A, Contreras R, et al.
Microb Cell Fact
. 2010 Nov;
9:93.
PMID: 21092289
Background: Yeast expression systems with altered N-glycosylation are now available to produce glycoproteins with homogenous, defined N-glycans. However, data on the behaviour of these strains in high cell density cultivation...
3.
Liu X, Dewaele S, Vanhooren V, Fan Y, Wang L, Van Huysse J, et al.
Liver Int
. 2010 Jun;
30(8):1221-8.
PMID: 20524982
Background And Aims: There is a demand for serum markers that can routinely assess the progression of liver cancer. DENA (diethylnitrosamine), a hepatocarcinogen, is commonly used in an experimental mouse...
4.
Gui H, Gao C, Wang H, Liu X, Xie Q, Dewaele S, et al.
Liver Int
. 2009 Dec;
30(2):259-67.
PMID: 19951379
Background: We previously reported on serum N-glycans as markers for the diagnosis of cirrhosis in patients with chronic hepatitis C infection. Our present study aimed to evaluate the use of...
5.
Chen C, Schmilovitz-Weiss H, Liu X, Pappo O, Halpern M, Sulkes J, et al.
J Proteome Res
. 2009 Jan;
8(2):463-70.
PMID: 19140676
The hepatic histology in nonalcoholic fatty liver disease can vary from isolated hepatic steatosis to steatohepatitis can progress to cirrhosis and liver-related death. The aim was to evaluate the use...
6.
Jacobs P, Geysens S, Vervecken W, Contreras R, Callewaert N
Nat Protoc
. 2009 Jan;
4(1):58-70.
PMID: 19131957
Here we provide a protocol for engineering the N-glycosylation pathway of the yeast Pichia pastoris. The general strategy consists of the disruption of an endogenous glycosyltransferase gene (OCH1) and the...
7.
Vanhooren V, Liu X, Desmyter L, Fan Y, Vanwalleghem L, Van Molle W, et al.
Rejuvenation Res
. 2008 Dec;
11(6):1013-20.
PMID: 19072255
Experiments in lower organisms, such as worms and flies, indicate that the molecular chaperone protein heat shock protein 70 (HSP70) is a longevity factor. In contrast, we demonstrate here that...
8.
Vanhooren V, Liu X, Franceschi C, Gao C, Libert C, Contreras R, et al.
Mech Ageing Dev
. 2008 Dec;
130(1-2):92-7.
PMID: 19070631
Protein glycosylation, the most common form of co-translational modification of proteins, is the enzymatic addition of sugars or oligosaccharides (glycans) to proteins. Protein glycosylation increases the diversity of the functions...
9.
Jacobs P, Ryckaert S, Geysens S, De Vusser K, Callewaert N, Contreras R
Biotechnol Lett
. 2008 Aug;
30(12):2173-81.
PMID: 18679585
Expression of proteins on the surface of yeasts has a wide range of applications in biotechnology, such as directed evolution of proteins for increased affinity and thermal stability, screening of...
10.
Contribution of galactofuranose to the virulence of the opportunistic pathogen Aspergillus fumigatus
Schmalhorst P, Krappmann S, Vervecken W, Rohde M, Muller M, Braus G, et al.
Eukaryot Cell
. 2008 Jun;
7(8):1268-77.
PMID: 18552284
The filamentous fungus Aspergillus fumigatus is responsible for a lethal disease called invasive aspergillosis that affects immunocompromised patients. This disease, like other human fungal diseases, is generally treated by compounds...