Wouter van Zon
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Explore the profile of Wouter van Zon including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
402
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Recent Articles
1.
Gruenheit N, Parkinson K, Brimson C, Kuwana S, Johnson E, Nagayama K, et al.
Dev Cell
. 2018 Nov;
47(4):494-508.e4.
PMID: 30473004
Cell-cell heterogeneity can facilitate lineage choice during embryonic development because it primes cells to respond to differentiation cues. However, remarkably little is known about the origin of heterogeneity or whether...
2.
Clijsters L, van Zon W, Riet B, Voets E, Boekhout M, Ogink J, et al.
Cell Cycle
. 2014 Dec;
13(15):2370-8.
PMID: 25483188
Sister chromatid separation creates a sudden loss of tension on kinetochores, which could, in principle, re-activate the spindle checkpoint in anaphase. This so-called "anaphase problem" is probably avoided by timely...
3.
van Zon W, Ogink J, Riet B, Medema R, Te Riele H, Wolthuis R
J Cell Biol
. 2010 Aug;
190(4):587-602.
PMID: 20733055
The ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C) is activated at prometaphase by mitotic phosphorylation and binding of its activator, Cdc20. This initiates cyclin A degradation, whereas cyclin B1 is stabilized by...
4.
van Zon W, Wolthuis R
Biochem Soc Trans
. 2010 Jan;
38(Pt 1):72-7.
PMID: 20074038
Active cyclin B1-Cdk1 (cyclin-dependent kinase 1) keeps cells in mitosis, allowing time for spindle microtubules to capture the chromosomes and for incorrect chromosome-spindle attachments to be repaired. Meanwhile, securin, an...
5.
Gurden M, Holland A, van Zon W, Tighe A, Vergnolle M, Andres D, et al.
J Cell Sci
. 2010 Jan;
123(Pt 3):321-30.
PMID: 20053638
Progression through mitosis and cytokinesis requires the sequential proteolysis of several cell-cycle regulators. This proteolysis is mediated by the ubiquitin-proteasome system, with the E3 ligase being the anaphase-promoting complex, also...
6.
van der Lelij P, Godthelp B, van Zon W, van Gosliga D, Oostra A, Steltenpool J, et al.
PLoS One
. 2009 Sep;
4(9):e6936.
PMID: 19738907
Cohesion between sister chromatids is essential for faithful chromosome segregation. In budding yeast, the acetyltransferase Eco1/Ctf7 establishes cohesion during DNA replication in S phase and in response to DNA double...
7.
van Leuken R, Clijsters L, van Zon W, Lim D, Yao X, Wolthuis R, et al.
PLoS One
. 2009 Apr;
4(4):e5282.
PMID: 19390576
Polo-like kinase-1 (Plk1) is activated before mitosis by Aurora A and its cofactor Bora. In mitosis, Bora is degraded in a manner dependent on Plk1 kinase activity and the E3...
8.
Wolthuis R, Clay-Farrace L, van Zon W, Yekezare M, Koop L, Ogink J, et al.
Mol Cell
. 2008 May;
30(3):290-302.
PMID: 18471975
Successful mitosis requires the right protein be degraded at the right time. Central to this is the spindle checkpoint that prevents the destruction of securin and cyclin B1 when there...
9.
Lindqvist A, van Zon W, Rosenthal C, Wolthuis R
PLoS Biol
. 2007 May;
5(5):e123.
PMID: 17472438
Activation of cyclin B1-cyclin-dependent kinase 1 (Cdk1), triggered by a positive feedback loop at the end of G2, is the key event that initiates mitotic entry. In metaphase, anaphase-promoting complex/cyclosome-dependent...