Wojtek Auerbach
Overview
Explore the profile of Wojtek Auerbach including associated specialties, affiliations and a list of published articles.
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21
Citations
2386
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Recent Articles
1.
Lee J, Wang J, Ally R, Trzaska S, Hickey J, Mujica A, et al.
Stem Cell Reports
. 2022 Dec;
18(1):394-409.
PMID: 36525967
Rats were more frequently used than mice to model human disease before mouse embryonic stem cells (mESCs) revolutionized genetic engineering in mice. Rat ESCs (rESCs) were first reported over 10...
2.
Macdonald L, Meagher K, Franklin M, Levenkova N, Hansen J, Badithe A, et al.
Proc Natl Acad Sci U S A
. 2019 Dec;
117(1):292-299.
PMID: 31879340
We describe a Kappa-on-Heavy (KoH) mouse that produces a class of highly diverse, fully human, antibody-like agents. This mouse was made by replacing the germline variable sequences of both the...
3.
Voronina V, Harris F, Schmahl J, Galligan C, Oristian D, Zamfirova R, et al.
Biol Reprod
. 2018 Oct;
100(3):686-696.
PMID: 30289441
The Adisintegrin and metalloprotease domain-containing (ADAM) family of proteins is involved in cell adhesion, migration, proteolysis, and signaling. Many ADAMs are required for reproduction; however, the role of Adam6 has...
4.
Auerbach W, DeChiara T
Cold Spring Harb Protoc
. 2017 Sep;
2017(9):pdb.prot094367.
PMID: 28864571
In this protocol, eight-cell-stage precompaction embryos from outbred mouse strains are used for the injection of hybrid or inbred embryonic stem (ES) cells. This process often leads to generation of...
5.
Atanasio A, Decman V, White D, Ramos M, Ikiz B, Lee H, et al.
Sci Rep
. 2016 Mar;
6:23204.
PMID: 26979938
The expansion of a hexanucleotide (GGGGCC) repeat in C9ORF72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Both the function of C9ORF72 and the...
6.
Lai K, Gong G, Atanasio A, Rojas J, Quispe J, Posca J, et al.
PLoS One
. 2015 Apr;
10(4):e0125522.
PMID: 25909911
In a survey of 20 knockout mouse lines designed to examine the biological functions of large intergenic non-coding RNAs (lincRNAs), we have found a variety of phenotypes, ranging from perinatal...
7.
Kuno J, Poueymirou W, Gong G, Siao C, Clarke G, Esau L, et al.
Transgenic Res
. 2014 Aug;
24(1):19-29.
PMID: 25087174
Known examples of male to female sex reversal in mice are caused by either strain incompatibilities or mutations in genes required for male sex determination. The resultant XY females are...
8.
Macdonald L, Karow M, Stevens S, Auerbach W, Poueymirou W, Yasenchak J, et al.
Proc Natl Acad Sci U S A
. 2014 Apr;
111(14):5147-52.
PMID: 24706858
Genetic humanization, which involves replacing mouse genes with their human counterparts, can create powerful animal models for the study of human genes and diseases. One important example of genetic humanization...
9.
Economides A, Frendewey D, Yang P, Dominguez M, Dore A, Lobov I, et al.
Proc Natl Acad Sci U S A
. 2013 Aug;
110(34):E3179-88.
PMID: 23918385
Conditional mutagenesis is becoming a method of choice for studying gene function, but constructing conditional alleles is often laborious, limited by target gene structure, and at times, prone to incomplete...
10.
Rongvaux A, Willinger T, Takizawa H, Rathinam C, Auerbach W, Murphy A, et al.
Proc Natl Acad Sci U S A
. 2011 Jan;
108(6):2378-83.
PMID: 21262827
Hematopoietic stem cells (HSCs) both self-renew and give rise to all blood cells for the lifetime of an individual. Xenogeneic mouse models are broadly used to study human hematopoietic stem...