David M Valenzuela
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Explore the profile of David M Valenzuela including associated specialties, affiliations and a list of published articles.
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78
Citations
9156
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Recent Articles
1.
Espinoza S, Arredondo S, Barake F, Carvajal F, Guerrero F, Segovia-Miranda F, et al.
BMC Biol
. 2020 Nov;
18(1):164.
PMID: 33158444
Background: Cognitive dysfunction (CD) is common among patients with the autoimmune disease systemic lupus erythematosus (SLE). Anti-ribosomal P autoantibodies associate with this dysfunction and have neuropathogenic effects that are mediated...
2.
Azuma Y, Matsuo Y, Nakajima H, Yancopoulos G, Valenzuela D, Murphy A, et al.
J Pharmacol Sci
. 2020 Apr;
115(2):105-111.
PMID: 32272526
The cytokine, interleukin (IL)-19, is a member of the IL-10 family that includes IL-20, IL-22, IL-24, and IL-26. Recent studies have shown that IL-19 is produced by keratinocytes, epithelial cells,...
3.
Pardo E, Carcamo C, Martin R, Ciampi E, Segovia-Miranda F, Curkovic-Pena C, et al.
PLoS One
. 2017 Jun;
12(6):e0177472.
PMID: 28650992
Galectin-8 (Gal-8) is a member of a glycan-binding protein family that regulates the immune system, among other functions, and is a target of antibodies in autoimmune disorders. However, its role...
4.
Takahashi K, Kim R, Lauhan C, Park Y, Nguyen N, Vestweber D, et al.
PLoS One
. 2017 May;
12(5):e0177192.
PMID: 28542220
Renal vascular development is a coordinated process that requires ordered endothelial cell proliferation, migration, intercellular adhesion, and morphogenesis. In recent decades, studies have defined the pivotal role of endothelial receptor...
5.
Gomez Perdiguero E, Liabotis-Fontugne A, Durand M, Faye C, Ricard-Blum S, Simonutti M, et al.
J Pathol
. 2016 Sep;
240(4):461-471.
PMID: 27577973
Dynamic control of endothelial cell junctions is essential for vascular homeostasis and angiogenesis. We recently provided genetic evidence that ANGPTL4 is a key regulator of vascular integrity both during developmental...
6.
Subramanian B, Sun H, Yan P, Charoonratana V, Higgs H, Wang F, et al.
Kidney Int
. 2016 Jun;
90(2):363-372.
PMID: 27350175
Mutations in the INF2 (inverted formin 2) gene, encoding a diaphanous formin family protein that regulates actin cytoskeleton dynamics, cause human focal segmental glomerulosclerosis (FSGS). INF2 interacts directly with certain...
7.
Mastaitis J, Eckersdorff M, Min S, Xin Y, Cavino K, Aglione J, et al.
Endocrinology
. 2015 Sep;
156(12):4502-10.
PMID: 26406932
Secreted frizzled-related protein 4 (SFRP4) is an extracellular regulator of the wingless-type mouse mammary tumor virus integration site family (WNT) pathway. SFRP4 has been implicated in adipocyte dysfunction, obesity, insulin...
8.
Villanueva S, Burgos J, Lopez-Cayuqueo K, Lai K, Valenzuela D, Cid L, et al.
PLoS One
. 2015 Sep;
10(9):e0139284.
PMID: 26402555
Kir7.1 is an inwardly rectifying K+ channel of the Kir superfamily encoded by the kcnj13 gene. Kir7.1 is present in epithelial tissues where it colocalizes with the Na+/K+-pump probably serving...
9.
Valenzuela D, Ordovas K
Int J Cardiovasc Imaging
. 2015 Sep;
32(1):13-8.
PMID: 26342712
Improved surgical and medical therapy have prolonged survival in patients with congenital heart disease (CHD) such that general medical conditions like coronary artery disease (CAD) are now the main determinants...
10.
Okamoto H, Kim J, Aglione J, Lee J, Cavino K, Na E, et al.
Endocrinology
. 2015 May;
156(8):2781-94.
PMID: 26020795
Antagonizing glucagon action represents an attractive therapeutic option for reducing hepatic glucose production in settings of hyperglycemia where glucagon excess plays a key pathophysiological role. We therefore generated REGN1193, a...