Wojciech Kopec
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Explore the profile of Wojciech Kopec including associated specialties, affiliations and a list of published articles.
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31
Citations
472
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Recent Articles
1.
Rodstrom K, Eymsh B, Proks P, Hayre M, Cordeiro S, Mendez-Otalvaro E, et al.
Nat Struct Mol Biol
. 2025 Feb;
PMID: 40011745
THIK-1 (KCNK13) is a halothane-inhibited and anionic-lipid-activated two-pore domain (K2P) K channel implicated in microglial activation and neuroinflammation, and a current target for the treatment of neurodegenerative disorders, for example...
2.
Mendez-Otalvaro E, Kopec W, de Groot B
Biophys J
. 2024 Aug;
123(19):3408-3420.
PMID: 39161093
TWIK-related potassium channel 1 (TREK1), a two-pore-domain mammalian potassium (K) channel, regulates the resting potential across cell membranes, presenting a promising therapeutic target for neuropathy treatment. The gating of this...
3.
Gapsys V, Kopec W, Matthes D, de Groot B
Curr Opin Struct Biol
. 2024 Jul;
88:102887.
PMID: 39029280
The rapid advancement in computational power available for research offers to bring not only quantitative improvements, but also qualitative changes in the field of biomolecular simulation. Here, we review the...
4.
Mironenko A, de Groot B, Kopec W
PNAS Nexus
. 2024 Jul;
3(7):pgae272.
PMID: 39015549
Potassium (K) channels combine high conductance with high ion selectivity. To explain this efficiency, two molecular mechanisms have been proposed. The "direct knock-on" mechanism is defined by water-free K permeation...
5.
Kopec W, Thomson A, de Groot B, Rothberg B
J Gen Physiol
. 2023 Jun;
155(8).
PMID: 37318452
K+ channel activity can be limited by C-type inactivation, which is likely initiated in part by dissociation of K+ ions from the selectivity filter and modulated by the side chains...
6.
Direct Detection of Bound Ammonium Ions in the Selectivity Filter of Ion Channels by Solid-State NMR
Oster C, Movellan K, Goold B, Hendriks K, Lange S, Becker S, et al.
J Am Chem Soc
. 2022 Feb;
144(9):4147-4157.
PMID: 35200002
The flow of ions across cell membranes facilitated by ion channels is an important function for all living cells. Despite the huge amount of structural data provided by crystallography, elucidating...
7.
Roy R, Hendriks K, Kopec W, Abdolvand S, Weiss K, de Groot B, et al.
IUCrJ
. 2021 May;
8(Pt 3):421-430.
PMID: 33953928
The sodium potassium ion channel (NaK) is a nonselective ion channel that conducts both sodium and potassium across the cellular membrane. A new crystallographic structure of NaK reveals conformational differences...
8.
Mironenko A, Zachariae U, de Groot B, Kopec W
J Mol Biol
. 2021 Apr;
433(17):167002.
PMID: 33891905
Potassium channels play critical roles in many physiological processes, providing a selective permeation route for K ions in and out of a cell, by employing a carefully designed selectivity filter,...
9.
Awasthi N, Kopec W, Wilkosz N, Jamroz D, Hub J, Zatorska M, et al.
ACS Biomater Sci Eng
. 2021 Jan;
5(2):780-794.
PMID: 33405839
Polycations are an attractive class of macromolecules with promising applications as drug/gene carriers and biocides. The chemical structure and concentration of a polycation determine its interaction with cellular membranes and,...
10.
Kopec W, Zak A, Jamroz D, Nakahata R, Yusa S, Gapsys V, et al.
Langmuir
. 2020 Oct;
36(42):12435-12450.
PMID: 33058724
Natural or synthetic polycations are used as biocides or as drug/gene carriers. Understanding the interactions between these macromolecules and cell membranes at the molecular level is therefore of great importance...