Wojciech J Szlachcic
Overview
Explore the profile of Wojciech J Szlachcic including associated specialties, affiliations and a list of published articles.
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16
Citations
325
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Recent Articles
11.
Wiatr K, Szlachcic W, Trzeciak M, Figlerowicz M, Figiel M
Mol Neurobiol
. 2017 May;
55(4):3351-3371.
PMID: 28497201
Huntington disease (HD) is a dominantly inherited disorder caused by a CAG expansion mutation in the huntingtin (HTT) gene, which results in the HTT protein that contains an expanded polyglutamine...
12.
Szlachcic W, Switonski P, Kurkowiak M, Wiatr K, Figiel M
Mol Brain
. 2015 Oct;
8(1):69.
PMID: 26515641
Background: The polyglutamine (polyQ) family of disorders comprises 9 genetic diseases, including several types of ataxia and Huntington disease. Approximately two decades of investigation and the creation of more than...
13.
Szlachcic W, Switonski P, Krzyzosiak W, Figlerowicz M, Figiel M
Dis Model Mech
. 2015 Jun;
8(9):1047-57.
PMID: 26092128
Huntington disease (HD) is a brain disorder characterized by the late onset of motor and cognitive symptoms, even though the neurons in the brain begin to suffer dysfunction and degeneration...
14.
Switonski P, Szlachcic W, Krzyzosiak W, Figiel M
Neurobiol Dis
. 2014 Oct;
73:174-88.
PMID: 25301414
Spinocerebellar ataxia type 3 (SCA3/MJD) is a neurodegenerative disease triggered by the expansion of CAG repeats in the ATXN3 gene. Here, we report the generation of the first humanized ataxin-3...
15.
Figiel M, Szlachcic W, Switonski P, Gabka A, Krzyzosiak W
Mol Neurobiol
. 2012 Sep;
46(2):393-429.
PMID: 22956270
Polyglutamine (polyQ) disorders share many similarities, such as a common mutation type in unrelated human causative genes, neurological character, and certain aspects of pathogenesis, including morphological and physiological neuronal alterations....
16.
Switonski P, Szlachcic W, Gabka A, Krzyzosiak W, Figiel M
Mol Neurobiol
. 2012 Sep;
46(2):430-66.
PMID: 22944909
Mouse models of human diseases are created both to understand the pathogenesis of the disorders and to find successful therapies for them. This work is the second part in a...
17.
Starega-Roslan J, Krol J, Koscianska E, Kozlowski P, Szlachcic W, Sobczak K, et al.
Nucleic Acids Res
. 2010 Aug;
39(1):257-68.
PMID: 20739353
The biogenesis of human microRNAs (miRNAs) includes two RNA cleavage steps in which the activities of the RNases Drosha and Dicer are involved. miRNAs of diverse lengths are generated from...