Marissa A Scavuzzo
Overview
Explore the profile of Marissa A Scavuzzo including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
439
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Recent Articles
1.
Scavuzzo M, Szlachcic W, Hill M, Ziojla N, Teaw J, Carlson J, et al.
Exp Mol Med
. 2025 Jan;
57(1):204-220.
PMID: 39779976
The spatial organization of cells within a tissue is dictated throughout dynamic developmental processes. We sought to understand whether cells geometrically coordinate with one another throughout development to achieve their...
2.
Aydin B, Mamede I, Cardoso J, Deere J, Alvarez Y, Qiao S, et al.
bioRxiv
. 2024 Oct;
PMID: 39463929
Enteric neurons control gut physiology by regulating peristalsis, nutrient absorption, and secretion . Disruptions in microbial communities caused by antibiotics or enteric infections result in the loss of enteric neurons...
3.
Cohn E, Clayton B, Madhavan M, Lee K, Yacoub S, Fedorov Y, et al.
Nat Neurosci
. 2024 Mar;
27(5):836-845.
PMID: 38528201
Exposure to environmental chemicals can impair neurodevelopment, and oligodendrocytes may be particularly vulnerable, as their development extends from gestation into adulthood. However, few environmental chemicals have been assessed for potential...
4.
Scavuzzo M, Letai K, Maeno-Hikichi Y, Wulftange W, Shah I, Rameshbabu J, et al.
bioRxiv
. 2023 Jun;
PMID: 37333182
Enteric glia are the predominant cell type in the enteric nervous system yet their identities and roles in gastrointestinal function are not well classified. Using our optimized single nucleus RNA-sequencing...
5.
Szlachcic W, Letai K, Scavuzzo M, Borowiak M
Bioessays
. 2023 Mar;
45(4):e2200186.
PMID: 36871153
Unraveling molecular and functional heterogeneity of niche cells within the developing endoderm could resolve mechanisms of tissue formation and maturation. Here, we discuss current unknowns in molecular mechanisms underlying key...
6.
Chmielowiec J, Szlachcic W, Yang D, Scavuzzo M, Wamble K, Sarrion-Perdigones A, et al.
Nat Commun
. 2022 Apr;
13(1):1952.
PMID: 35414140
In vitro derivation of pancreatic β-cells from human pluripotent stem cells holds promise as diabetes treatment. Despite recent progress, efforts to generate physiologically competent β-cells are still hindered by incomplete...
7.
Kong Y, Jing Y, Allard D, Scavuzzo M, Sprouse M, Borowiak M, et al.
Eur J Immunol
. 2022 Apr;
52(7):1158-1170.
PMID: 35389516
The contribution of low-affinity T cells to autoimmunity in the context of polyclonal T-cell responses is understudied due to the limitations in their capture by tetrameric reagents and low level...
8.
Allan K, Hu L, Scavuzzo M, Morton A, Gevorgyan A, Cohn E, et al.
Cell Stem Cell
. 2020 Oct;
28(2):257-272.e11.
PMID: 33091368
Mammalian cells respond to insufficient oxygen through transcriptional regulators called hypoxia-inducible factors (HIFs). Although transiently protective, prolonged HIF activity drives distinct pathological responses in different tissues. Using a model of...
9.
Scavuzzo M, Borowiak M
Sci Transl Med
. 2020 Feb;
12(530).
PMID: 32051228
Combining a DYRK1A inhibitor and GLP-1 receptor agonist boosts human pancreatic β cell proliferation and glucose homeostasis in vivo (Ackeifi , this issue).
10.
A Critical Insulin TCR Contact Residue Selects High-Affinity and Pathogenic Insulin-Specific T Cells
Bettini M, Scavuzzo M, Liu B, Kolawole E, Guo L, Evavold B, et al.
Diabetes
. 2019 Dec;
69(3):392-400.
PMID: 31836691
Type 1 diabetes is an autoimmune-mediated disease that culminates in the targeted destruction of insulin-producing β-cells. CD4 responses in NOD mice are dominated by insulin epitope B:9-23 (InsB) specificity, and...