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Winston T Stauffer

Explore the profile of Winston T Stauffer including associated specialties, affiliations and a list of published articles. Areas
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Articles 9
Citations 91
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Recent Articles
1.
Stauffer W, Goodman A, Gallay P
Front Pharmacol . 2024 Jul; 15:1417945. PMID: 39045055
Cyclophilins (Cyps), characterized as peptidyl-prolyl isomerases (PPIases), are highly conserved and ubiquitous, playing a crucial role in protein folding and cellular signaling. This review summarizes the biochemical pathways mediated by...
2.
Stauffer W, Bobardt M, Ure D, Foster R, Gallay P
PLoS One . 2024 Apr; 19(4):e0301711. PMID: 38573968
A family of Peptidyl-prolyl isomerases (PPIases), called Cyclophilins, localize to numerous intracellular and extracellular locations where they contribute to a variety of essential functions. We previously reported that non-immunosuppressive pan-cyclophilin...
3.
Stauffer W, Goodman A, Bobardt M, Ure D, Foster R, Gallay P
PLoS One . 2024 Mar; 19(3):e0298211. PMID: 38427624
Cyclophilins are a diverse family of peptidyl-prolyl isomerases (PPIases) of importance in a variety of essential cellular functions. We previously reported that the pan-cyclophilin inhibitor drug reconfilstat (CRV431) decreased disease...
4.
Arrieta A, Blackwood E, Stauffer W, Domingo M, Bilal A, Thuerauf D, et al.
J Biol Chem . 2020 Apr; 295(22):7566-7583. PMID: 32327487
We have previously demonstrated that ischemia/reperfusion (I/R) impairs endoplasmic reticulum (ER)-based protein folding in the heart and thereby activates an unfolded protein response sensor and effector, activated transcription factor 6α...
5.
Glembotski C, Arrieta A, Blackwood E, Stauffer W
Front Physiol . 2020 Apr; 11:267. PMID: 32322217
Proteostasis encompasses a homeostatic cellular network in all cells that maintains the integrity of the proteome, which is critical for optimal cellular function. The components of the proteostasis network include...
6.
Blackwood E, Bilal A, Stauffer W, Arrieta A, Glembotski C
Cells . 2020 Mar; 9(3). PMID: 32138230
The heart exhibits incredible plasticity in response to both environmental and genetic alterations that affect workload. Over the course of development, or in response to physiological or pathological stimuli, the...
7.
Stauffer W, Blackwood E, Azizi K, Kaufman R, Glembotski C
Int J Mol Sci . 2020 Feb; 21(4). PMID: 32085622
Activating transcription factor-6 α (ATF6) is one of the three main sensors and effectors of the endoplasmic reticulum (ER) stress response and, as such, it is critical for protecting the...
8.
Stauffer W, Arrieta A, Blackwood E, Glembotski C
Int J Mol Sci . 2020 Feb; 21(3). PMID: 32046286
There are more than 2000 transcription factors in eukaryotes, many of which are subject to complex mechanisms fine-tuning their activity and their transcriptional programs to meet the vast array of...
9.
Arrieta A, Blackwood E, Stauffer W, Glembotski C
Front Cardiovasc Med . 2020 Feb; 6:193. PMID: 32010709
The integrity of the proteome in cardiac myocytes is critical for robust heart function. Proteome integrity in all cells is managed by protein homeostasis or proteostasis, which encompasses processes that...