Michael Bobardt
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Explore the profile of Michael Bobardt including associated specialties, affiliations and a list of published articles.
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31
Citations
712
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Recent Articles
1.
Stauffer W, Bobardt M, Ure D, Foster R, Gallay P
PLoS One
. 2024 Apr;
19(4):e0301711.
PMID: 38573968
A family of Peptidyl-prolyl isomerases (PPIases), called Cyclophilins, localize to numerous intracellular and extracellular locations where they contribute to a variety of essential functions. We previously reported that non-immunosuppressive pan-cyclophilin...
2.
Stauffer W, Goodman A, Bobardt M, Ure D, Foster R, Gallay P
PLoS One
. 2024 Mar;
19(3):e0298211.
PMID: 38427624
Cyclophilins are a diverse family of peptidyl-prolyl isomerases (PPIases) of importance in a variety of essential cellular functions. We previously reported that the pan-cyclophilin inhibitor drug reconfilstat (CRV431) decreased disease...
3.
Stauffer W, Bobardt M, Ure D, Foster R, Gallay P
Viruses
. 2023 Oct;
15(10).
PMID: 37896876
There is an urgent need for the identification of new drugs that inhibit HCV-induced hepatocellular carcinoma (HCC). Our work demonstrates that cyclophilin inhibitors (CypIs) represent such new drugs. We demonstrate...
4.
Stauffer W, Bobardt M, Ure D, Foster R, Gallay P
bioRxiv
. 2023 Aug;
PMID: 37645728
There is an urgent need for the identification of new drugs that inhibit HCV-induced hepatocellular carcinoma (HCC). Our work demonstrates that cyclophilin inhibitors (CypI) represent such new drugs. We demonstrated...
5.
Ewart G, Bobardt M, Bentzen B, Yan Y, Thomson A, Klumpp K, et al.
PLoS Pathog
. 2023 Aug;
19(8):e1011328.
PMID: 37549173
The Coronavirus envelope (E) protein is a small structural protein with ion channel activity that plays an important role in virus assembly, budding, immunopathogenesis and disease severity. The viroporin E...
6.
Gunawardana M, Webster S, Rivera S, Cortez Jr J, Breslin J, Pinales C, et al.
Commun Med (Lond)
. 2022 Oct;
2:129.
PMID: 36238348
Background: A comprehensive understanding of the SARS-CoV-2 infection dynamics and the ensuing host immune responses is needed to explain the pathogenesis as it relates to viral transmission. Knowledge gaps exist...
7.
Bobardt M, Ramirez C, Baum M, Ure D, Foster R, Gallay P
PLoS One
. 2021 May;
16(5):e0251934.
PMID: 34014993
We and others previously reported that the direct-acting agents (DAA) NS5A inhibitors (NS5Ai) and the host-targeting agents cyclophilin inhibitors (CypIs) inhibit HCV replication in vitro. In this study, we investigated...
8.
Bobardt M, Hansson M, Mayo P, Ure D, Foster R, Gallay P
PLoS One
. 2020 Aug;
15(8):e0237236.
PMID: 32764799
We previously reported that the non-immunosuppressive cyclophilin inhibitors (CypIs)-cyclosporin A analog CRV431 and sanglifehrin analog NV556-efficiently inhibit HCV replication in vitro. In this study, we asked whether they can also...
9.
Baum M, Ramirez C, Moss J, Gunawardana M, Bobardt M, Gallay P
Sci Rep
. 2020 Aug;
10(1):12995.
PMID: 32747682
The HIV-1 epidemic remains an urgent global health concern. Young women are disproportionately at risk of acquiring the virus. A range of highly effective, female-controlled, discrete vaginal products therefore is...
10.
Bobardt M, Kuo J, Chatterji U, Wiedemann N, Vuagniaux G, Gallay P
PLoS One
. 2020 Jan;
15(1):e0227715.
PMID: 31978106
The immune checkpoint programmed cell death protein 1 (PD-1) plays a major role in T cell exhaustion in cancer and chronic HIV infection. The inhibitor of apoptosis protein antagonist Debio...