Wing Ki Wong
Overview
Explore the profile of Wing Ki Wong including associated specialties, affiliations and a list of published articles.
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17
Citations
255
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Recent Articles
1.
Abanades B, Olsen T, Raybould M, Aguilar-Sanjuan B, Wong W, Georges G, et al.
Nucleic Acids Res
. 2023 Nov;
52(D1):D545-D551.
PMID: 37971316
Antibodies are key proteins of the adaptive immune system, and there exists a large body of academic literature and patents dedicated to their study and concomitant conversion into therapeutics, diagnostics,...
2.
Spoendlin F, Abanades B, Raybould M, Wong W, Georges G, Deane C
Front Mol Biosci
. 2023 Oct;
10:1237621.
PMID: 37790877
The function of an antibody is intrinsically linked to the epitope it engages. Clonal clustering methods, based on sequence identity, are commonly used to group antibodies that will bind to...
3.
Abanades B, Wong W, Boyles F, Georges G, Bujotzek A, Deane C
Commun Biol
. 2023 May;
6(1):575.
PMID: 37248282
Immune receptor proteins play a key role in the immune system and have shown great promise as biotherapeutics. The structure of these proteins is critical for understanding their antigen binding...
4.
Ngan O, Wong W, Tam J, Li C
Int J Neonatal Screen
. 2022 Dec;
8(4).
PMID: 36547380
Parents increasingly utilise the internet to obtain information on health practices, but the quality of online information about screening for inherited metabolic diseases (IMD) needs to be improved. A content...
5.
Wang Y, Tsitsiklis A, Devoe S, Gao W, Chu H, Zhang Y, et al.
Front Immunol
. 2022 Aug;
13:847092.
PMID: 35967379
Certain CD8 T cell responses are particularly effective at controlling infection, as exemplified by elite control of HIV in individuals harboring HLA-B57. To understand the structural features that contribute to...
6.
Robinson S, Raybould M, Schneider C, Wong W, Marks C, Deane C
PLoS Comput Biol
. 2021 Dec;
17(12):e1009675.
PMID: 34898603
Identifying the epitope of an antibody is a key step in understanding its function and its potential as a therapeutic. Sequence-based clonal clustering can identify antibodies with similar epitope complementarity,...
7.
Wong W, Robinson S, Bujotzek A, Georges G, Lewis A, Shi J, et al.
MAbs
. 2021 Jan;
13(1):1873478.
PMID: 33448242
Solving the structure of an antibody-antigen complex gives atomic level information of the interactions between an antibody and its antigen, but such structures are expensive and hard to obtain. Alternative...
8.
Wong W, Marks C, Leem J, Lewis A, Shi J, Deane C
Bioinformatics
. 2020 Mar;
36(11):3580-3581.
PMID: 32181809
Motivation: T-cell receptors (TCRs) are immune proteins that primarily target peptide antigens presented by the major histocompatibility complex. They tend to have lower specificity and affinity than their antibody counterparts,...
9.
Kovaltsuk A, Raybould M, Wong W, Marks C, Kelm S, Snowden J, et al.
PLoS Comput Biol
. 2020 Feb;
16(2):e1007636.
PMID: 32069281
Most current analysis tools for antibody next-generation sequencing data work with primary sequence descriptors, leaving accompanying structural information unharnessed. We have used novel rapid methods to structurally characterize the complementary-determining...
10.
Wong W, Leem J, Deane C
Front Immunol
. 2019 Nov;
10:2454.
PMID: 31681328
The adaptive immune system uses two main types of antigen receptors: T-cell receptors (TCRs) and antibodies. While both proteins share a globally similar β-sandwich architecture, TCRs are specialized to recognize...