Matthew I J Raybould
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Explore the profile of Matthew I J Raybould including associated specialties, affiliations and a list of published articles.
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22
Citations
682
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Recent Articles
1.
Quast N, Abanades B, Guloglu B, Karuppiah V, Harper S, Raybould M, et al.
Commun Biol
. 2025 Mar;
8(1):362.
PMID: 40038394
T-cell receptor (TCR) structures are currently under-utilised in early-stage drug discovery and repertoire-scale informatics. Here, we leverage a large dataset of solved TCR structures from Immunocore to evaluate the current...
2.
Ellmen I, Raybould M, Deane C
Nat Chem Biol
. 2024 Dec;
21(1):27-28.
PMID: 39719497
No abstract available.
3.
Erasmus M, Spector L, Ferrara F, DiNiro R, Pohl T, Perea-Schmittle K, et al.
Nat Biotechnol
. 2024 Nov;
42(11):1637-1642.
PMID: 39496931
No abstract available.
4.
Condado-Morales I, Dingfelder F, Waibel I, Turnbull O, Patel B, Cao Z, et al.
MAbs
. 2024 Oct;
16(1):2403156.
PMID: 39364796
Engineered antibody formats, such as antibody fragments and bispecifics, have the potential to offer improved therapeutic efficacy compared to traditional full-length monoclonal antibodies (mAbs). However, the translation of these non-natural...
5.
Raybould M, Greenshields-Watson A, Agarwal P, Aguilar-Sanjuan B, Olsen T, Turnbull O, et al.
Cell Rep
. 2024 Aug;
43(9):114704.
PMID: 39216000
T cell activation is governed through T cell receptors (TCRs), heterodimers of two sequence-variable chains (often an α and β chain) that synergistically recognize antigen fragments presented on cell surfaces....
6.
Fischer K, Lulla A, So T, Pereyra-Gerber P, Raybould M, Kohler T, et al.
Nat Biotechnol
. 2024 Aug;
PMID: 39143416
Monoclonal antibodies are increasingly used to prevent and treat viral infections and are pivotal in pandemic response efforts. Antibody-secreting cells (ASCs; plasma cells and plasmablasts) are an excellent source of...
7.
Gordon G, Raybould M, Wong A, Deane C
Front Immunol
. 2024 May;
15():1399438.
PMID: 38812514
To be viable therapeutics, antibodies must be tolerated by the human immune system. Rational approaches to reduce the risk of unwanted immunogenicity involve maximizing the 'humanness' of the candidate drug....
8.
Theorell J, Harrison R, Williams R, Raybould M, Zhao M, Fox H, et al.
Proc Natl Acad Sci U S A
. 2024 Feb;
121(7):e2311049121.
PMID: 38319973
Intrathecal synthesis of central nervous system (CNS)-reactive autoantibodies is observed across patients with autoimmune encephalitis (AE), who show multiple residual neurobehavioral deficits and relapses despite immunotherapies. We leveraged two common...
9.
Raybould M, Turnbull O, Suter A, Guloglu B, Deane C
Commun Biol
. 2024 Jan;
7(1):62.
PMID: 38191620
Antibodies with lambda light chains (λ-antibodies) are generally considered to be less developable than those with kappa light chains (κ-antibodies). Though this hypothesis has not been formally established, it has...
10.
Abanades B, Olsen T, Raybould M, Aguilar-Sanjuan B, Wong W, Georges G, et al.
Nucleic Acids Res
. 2023 Nov;
52(D1):D545-D551.
PMID: 37971316
Antibodies are key proteins of the adaptive immune system, and there exists a large body of academic literature and patents dedicated to their study and concomitant conversion into therapeutics, diagnostics,...