Wim J E van Esch
Overview
Explore the profile of Wim J E van Esch including associated specialties, affiliations and a list of published articles.
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22
Citations
638
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Recent Articles
1.
Alban T, Riaz N, Parthasarathy P, Makarov V, Kendall S, Yoo S, et al.
Nat Med
. 2024 Sep;
30(11):3209-3222.
PMID: 39349627
Neoantigen immunoediting drives immune checkpoint blockade efficacy, yet the molecular features of neoantigens and how neoantigen immunogenicity shapes treatment response remain poorly understood. To address these questions, 80 patients with...
2.
Martin M, Aguilar-Rosas S, Franke K, Pieterse M, van Langelaar J, Schreurs R, et al.
Cancer Immunol Res
. 2024 Apr;
12(6):759-778.
PMID: 38573707
Identification of immunogenic cancer neoantigens as targets for therapy is challenging. Here, we integrate the whole-genome and long-read transcript sequencing of cancers to identify the collection of neo-open reading frame...
3.
Szittner Z, Bentlage A, Temming A, Schmidt D, Visser R, Lissenberg-Thunnissen S, et al.
Front Immunol
. 2023 Oct;
14:1225603.
PMID: 37868955
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) can occur due to maternal IgG antibodies targeting platelet antigens, causing life-threatening bleeding in the neonate. However, the disease manifests itself in only a...
4.
van der Velden S, van Osch T, Seghier A, Bentlage A, Mok J, Geerdes D, et al.
Blood
. 2023 Oct;
143(1):79-91.
PMID: 37801721
Transfusion-related acute lung injury (TRALI) is one of the leading causes of transfusion-related fatalities and, to date, is without available therapies. Here, we investigated the role of the complement system...
5.
Van Coillie J, Schulz M, Bentlage A, de Haan N, Ye Z, Geerdes D, et al.
Front Immunol
. 2022 Oct;
13:987151.
PMID: 36189205
Immunoglobulins G (IgG) and their Fc gamma receptors (FcγRs) play important roles in our immune system. The conserved glycan in the Fc region of IgG1 impacts interaction of IgG with...
6.
van Osch T, Pongracz T, Geerdes D, Mok J, van Esch W, Voorberg J, et al.
J Thromb Haemost
. 2022 Sep;
20(12):3011-3025.
PMID: 36165642
Background: The formation of alloantibodies directed against class I human leukocyte antigens (HLA) continues to be a clinically challenging complication after platelet transfusions, which can lead to platelet refractoriness (PR)...
7.
Sustic T, Van Coillie J, Larsen M, Derksen N, Szittner Z, Nouta J, et al.
EBioMedicine
. 2022 Jun;
81:104109.
PMID: 35752106
Background: Immunoglobulin G (IgG) antibodies serve a crucial immuno-protective function mediated by IgG Fc receptors (FcγR). Absence of fucose on the highly conserved N-linked glycan in the IgG Fc domain...
8.
van Osch T, Oosterhoff J, Bentlage A, Nouta J, Koeleman C, Geerdes D, et al.
Haematologica
. 2022 Mar;
107(10):2432-2444.
PMID: 35354253
Approximately 20% of patients receiving multiple platelet transfusions develop platelet alloantibodies, which can be directed against human leukocyte antigens (HLA) and, to a lesser extent, against human platelet antigens (HPA)....
9.
Temming A, Tammes Buirs M, Bentlage A, Treffers L, Feringa H, de Taeye S, et al.
Front Immunol
. 2021 Apr;
12:594773.
PMID: 33790888
Antibody-mediated blood disorders ensue after auto- or alloimmunization against blood cell antigens, resulting in cytopenia. Although the mechanisms of cell destruction are the same as in immunotherapies targeting tumor cells,...
10.
Brinkhaus M, Douwes R, Bentlage A, Temming A, de Taeye S, Tammes Buirs M, et al.
J Immunol
. 2020 Nov;
205(12):3456-3467.
PMID: 33188070
Abs of the IgG isotype mediate effector functions like Ab-dependent cellular cytotoxicity and Ab-dependent cellular phagocytosis by Fc interactions with FcγRs and complement-dependent cytotoxicity upon IgG-Fc binding to C1q. In...