Arthur E H Bentlage
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Explore the profile of Arthur E H Bentlage including associated specialties, affiliations and a list of published articles.
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44
Citations
1802
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Recent Articles
1.
Bosman G, Stoof I, Bastiaansen H, Quarles van Ufford L, Dobruchowska J, Langenbach J, et al.
ACS Chem Biol
. 2025 Feb;
PMID: 39970331
Monoclonal antibodies (mAb) produced in 1,4-mannosyl-glycoprotein 4--acetylglucosaminyltransferase (MGAT3) overexpressing cell lines have superior and activities. The -glycan of the Fc-region of these mAbs have increased levels of bisecting -acetylglucosamine (GlcNAc)...
2.
Wang A, Brink H, Bouma R, Affandi A, Nijen Twilhaar M, Heijnen D, et al.
Bioconjug Chem
. 2024 Nov;
35(11):1805-1814.
PMID: 39511711
Cancer vaccines are a promising strategy to increase tumor-specific immune responses in patients who do not adequately respond to checkpoint inhibitors. Cancer vaccines that contain patient-specific tumor antigens are most...
3.
Olafsdottir T, Thorleifsson G, Lopez de Lapuente Portilla A, Jonsson S, Stefansdottir L, Niroula A, et al.
Nat Commun
. 2024 Sep;
15(1):8054.
PMID: 39277589
Immunoglobulin G (IgG) is the main isotype of antibody in human blood. IgG consists of four subclasses (IgG1 to IgG4), encoded by separate constant region genes within the Ig heavy...
4.
Resa-Infante P, Erkizia I, Muniz-Trabudua X, Linty F, Bentlage A, Perez-Zsolt D, et al.
Biomed Pharmacother
. 2024 May;
175:116726.
PMID: 38754263
New therapies to treat or prevent viral infections are essential, as recently observed during the COVID-19 pandemic. Here, we propose a therapeutic strategy based on monoclonal antibodies that block the...
5.
Cleary S, Seo Y, Tian J, Kwaan N, Bulkley D, Bentlage A, et al.
bioRxiv
. 2024 Feb;
PMID: 38328049
Antibodies can initiate lung injury in a variety of disease states such as autoimmunity, transfusion reactions, or after organ transplantation, but the key factors determining in vivo pathogenicity of injury-inducing...
6.
Kissel T, Derksen V, Bentlage A, Koeleman C, Hafkenscheid L, van der Woude D, et al.
Nat Commun
. 2024 Jan;
15(1):393.
PMID: 38195612
IgG secreted by B cells carry asparagine N(297)-linked glycans in the fragment crystallizable (Fc) region. Changes in Fc glycosylation are related to health or disease and are functionally relevant, as...
7.
Szittner Z, Bentlage A, Temming A, Schmidt D, Visser R, Lissenberg-Thunnissen S, et al.
Front Immunol
. 2023 Oct;
14:1225603.
PMID: 37868955
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) can occur due to maternal IgG antibodies targeting platelet antigens, causing life-threatening bleeding in the neonate. However, the disease manifests itself in only a...
8.
van der Velden S, van Osch T, Seghier A, Bentlage A, Mok J, Geerdes D, et al.
Blood
. 2023 Oct;
143(1):79-91.
PMID: 37801721
Transfusion-related acute lung injury (TRALI) is one of the leading causes of transfusion-related fatalities and, to date, is without available therapies. Here, we investigated the role of the complement system...
9.
Schriek A, van Haaren M, Poniman M, Dekkers G, Bentlage A, Grobben M, et al.
Front Immunol
. 2022 Dec;
13:1091668.
PMID: 36483568
[This corrects the article DOI: 10.3389/fimmu.2022.893648.].
10.
Volkov M, Brinkhaus M, van Schie K, Bondt A, Kissel T, van der Kooi E, et al.
J Immunol
. 2022 Dec;
210(2):158-167.
PMID: 36480251
Abs can be glycosylated in both their Fc and Fab regions with marked effects on Ab function and binding. High levels of IgG Fab glycosylation are associated with malignant and...