William R Ferrell
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Explore the profile of William R Ferrell including associated specialties, affiliations and a list of published articles.
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37
Citations
995
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Recent Articles
1.
Losartan protects endothelium-dependent relaxation in vivo in a murine model of rheumatoid arthritis
Villaluz M, Dunning L, Goodyear C, Ferrell W, Lockhart J, MacKenzie A
Eur J Pharmacol
. 2021 May;
904:174133.
PMID: 33984299
Angiotensin II-type 1 receptor stimulation is recognised to promote inflammation, a state central to the development and maintenance of rheumatoid arthritis. Herein we examined the use of losartan, an angiotensin...
2.
Ariffin S, Bennett D, Ferrell W, Lockhart J, Dunning L, Clements D, et al.
J Feline Med Surg
. 2020 Dec;
23(8):794-803.
PMID: 33284033
Objectives: The aim of this study was to determine the presence of protease-activated receptor 2 (PAR2) and matriptase proteins and quantify PAR2 and matriptase mRNA expression in the articular cartilage...
3.
McCulloch K, McGrath S, Huesa C, Dunning L, Litherland G, Crilly A, et al.
Front Endocrinol (Lausanne)
. 2018 Jun;
9:257.
PMID: 29875735
Protease-activated receptor-2 (PAR2) is one member of a small family of transmembrane, G-protein-coupled receptors. These receptors are activated cleavage of their N terminus by serine proteases (e.g., tryptase), unveiling an...
4.
Wilkinson D, Desilets A, Lin H, Charlton S, Arques M, Falconer A, et al.
Sci Rep
. 2017 Dec;
7(1):16693.
PMID: 29196708
Increasing evidence implicates serine proteinases in the proteolytic cascades leading to the pathological destruction of extracellular matrices such as cartilage in osteoarthritis (OA). We have previously demonstrated that the type...
5.
Hamilton K, Dunning L, Ferrell W, Lockhart J, MacKenzie A
Vascul Pharmacol
. 2017 Nov;
100:51-57.
PMID: 29122658
A role for endothelium-derived constricting factors (EDCF), and the angiotensin II type 1 receptor (AT1R) pathway, in the vascular impairment found in the rat Freund's complete adjuvant (FCA)-model of rheumatoid...
6.
Huesa C, Ortiz A, Dunning L, McGavin L, Bennett L, McIntosh K, et al.
Ann Rheum Dis
. 2015 Dec;
75(11):1989-1997.
PMID: 26698846
Objective: Proteinase-activated receptor 2 (PAR2) deficiency protects against cartilage degradation in experimental osteoarthritis (OA). The wider impact of this pathway upon OA-associated pathologies such as osteophyte formation and pain is...
7.
MacKenzie A, Dunning L, Ferrell W, Lockhart J
Life Sci
. 2013 May;
92(23):1131-7.
PMID: 23643673
Aims: Rheumatoid arthritis (RA) is associated with high cardiovascular mortality. Impaired endothelial cell (EC) function and elevated angiotensin II levels may be central to the link between vascular dysfunction and...
8.
Steven R, Crilly A, Lockhart J, Ferrell W, McInnes I
Innate Immun
. 2013 Apr;
19(6):663-72.
PMID: 23606513
Proteinase-activated receptor-2 (PAR-2) was shown to influence immune regulation; however, its role in human macrophage subset development and function has not been addressed. Here, PAR-2 expression and activation was investigated...
9.
Crilly A, Palmer H, Nickdel M, Dunning L, Lockhart J, Plevin R, et al.
Ann Rheum Dis
. 2012 May;
71(9):1559-66.
PMID: 22563031
Objective: Proteinase-activated receptor-2 (PAR(2)) has been implicated in inflammatory articular pathology. Using the collagen-induced arthritis model (CIA) the authors have explored the capacity of PAR(2) to regulate adaptive immune pathways...
10.
Tindell A, Kelso E, Ferrell W, Lockhart J, Walsh D, Dunning L, et al.
Rheumatol Int
. 2011 Sep;
32(10):3077-86.
PMID: 21913036
Protease-activated receptor-2 (PAR-2) is known to be pro-inflammatory and increasing evidence points to an inflammatory component in osteoarthritis. This investigation examined the relationship between synovitis and PAR-2 expression, histological and...