John C Lockhart
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Explore the profile of John C Lockhart including associated specialties, affiliations and a list of published articles.
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24
Citations
515
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Recent Articles
1.
Asghar S, Litherland G, Cole J, McInnes I, Meek R, Lockhart J, et al.
Arthritis Res Ther
. 2024 Sep;
26(1):167.
PMID: 39342381
Background: Small extracellular vesicles (sEV) derived from synovial fibroblasts (SF) represent a novel molecular mechanism regulating cartilage erosion in osteoarthritis (OA). However, a comprehensive evaluation using disease relevant cells has...
2.
Short B, Delaney C, Johnston W, Litherland G, Lockhart J, Williams C, et al.
APMIS
. 2024 Feb;
132(5):336-347.
PMID: 38379455
Recent evidence indicates that microbial biofilm aggregates inhabit the lungs of COPD patients and actively contribute towards chronic colonization and repeat infections. However, there are no contextually relevant complex biofilm...
3.
Dunning L, McCulloch K, Lockhart J, Goodyear C, Huesa C
J Vis Exp
. 2022 Jul;
(185).
PMID: 35876542
Osteoarthritis is the most prevalent musculoskeletal disease in people over 45, leading to an increasing economic and societal cost. Animal models are used to mimic many aspects of the disease....
4.
Kelly-Robinson G, Reihill J, Lundy F, McGarvey L, Lockhart J, Litherland G, et al.
Int J Mol Sci
. 2021 Jul;
22(12).
PMID: 34198546
Chronic obstructive pulmonary disease (COPD) is a debilitating heterogeneous disease characterised by unregulated proteolytic destruction of lung tissue mediated via a protease-antiprotease imbalance. In COPD, the relationship between the neutrophil...
5.
Carroll E, Bailo M, Reihill J, Crilly A, Lockhart J, Litherland G, et al.
Int J Mol Sci
. 2021 Jun;
22(11).
PMID: 34072295
Trypsin-like proteases (TLPs) belong to a family of serine enzymes with primary substrate specificities for the basic residues, lysine and arginine, in the P1 position. Whilst initially perceived as soluble...
6.
Losartan protects endothelium-dependent relaxation in vivo in a murine model of rheumatoid arthritis
Villaluz M, Dunning L, Goodyear C, Ferrell W, Lockhart J, MacKenzie A
Eur J Pharmacol
. 2021 May;
904:174133.
PMID: 33984299
Angiotensin II-type 1 receptor stimulation is recognised to promote inflammation, a state central to the development and maintenance of rheumatoid arthritis. Herein we examined the use of losartan, an angiotensin...
7.
Ariffin S, Bennett D, Ferrell W, Lockhart J, Dunning L, Clements D, et al.
J Feline Med Surg
. 2020 Dec;
23(8):794-803.
PMID: 33284033
Objectives: The aim of this study was to determine the presence of protease-activated receptor 2 (PAR2) and matriptase proteins and quantify PAR2 and matriptase mRNA expression in the articular cartilage...
8.
Asghar S, Litherland G, Lockhart J, Goodyear C, Crilly A
Rheumatology (Oxford)
. 2019 Oct;
59(1):57-68.
PMID: 31628481
Osteoarthritis (OA) is the most prevalent of the musculoskeletal conditions and represents a significant public health burden. While degeneration of articular cartilage is a key feature, it is now increasingly...
9.
McCulloch K, McGrath S, Huesa C, Dunning L, Litherland G, Crilly A, et al.
Front Endocrinol (Lausanne)
. 2018 Jun;
9:257.
PMID: 29875735
Protease-activated receptor-2 (PAR2) is one member of a small family of transmembrane, G-protein-coupled receptors. These receptors are activated cleavage of their N terminus by serine proteases (e.g., tryptase), unveiling an...
10.
Hamilton K, Dunning L, Ferrell W, Lockhart J, MacKenzie A
Vascul Pharmacol
. 2017 Nov;
100:51-57.
PMID: 29122658
A role for endothelium-derived constricting factors (EDCF), and the angiotensin II type 1 receptor (AT1R) pathway, in the vascular impairment found in the rat Freund's complete adjuvant (FCA)-model of rheumatoid...