William Orent
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Explore the profile of William Orent including associated specialties, affiliations and a list of published articles.
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9
Citations
190
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Recent Articles
1.
Marino J, Gonzalez-Nolasco B, Wang X, Orent W, Benichou G
Am J Transplant
. 2020 Mar;
20(9):2551-2558.
PMID: 32185859
Alloreactive memory T cells play a key role in transplantation by accelerating allograft rejection and preventing tolerance induction. Some studies using µMT mice, which are constitutionally devoid of B cells,...
2.
Robinson K, Orent W, Madsen J, Benichou G
Am J Transplant
. 2018 Jun;
18(8):1843-1856.
PMID: 29939471
Achieving host immune tolerance of allogeneic transplants represents the ultimate challenge in clinical transplantation. It has become clear that different cells and mechanisms participate in acquisition versus maintenance of allograft...
3.
Orent W, Elyaman W
Methods Mol Biol
. 2017 May;
1585:111-125.
PMID: 28477191
Over the past decade, multiple effector T cell subsets have been identified with varying differentiation conditions in the milieu as well as a broad diversity of cytokine expression. Interleukin-9 (IL-9)...
4.
Kurdi A, Bassil R, Olah M, Wu C, Xiao S, Taga M, et al.
Nat Commun
. 2016 Oct;
7:13048.
PMID: 27725632
RORγt is a master transcription factor of Th17 cells and considered as a promising drug target for the treatment of autoimmune diseases. Here, we show the guanine nucleotide exchange factor,...
5.
Orent W, Mchenry A, Rao D, White C, Klein H, Bassil R, et al.
Hum Mol Genet
. 2015 Nov;
25(2):404-17.
PMID: 26604133
Notch signaling has recently emerged as an important regulator of immune responses in autoimmune diseases. The recombination signal-binding protein for immunoglobulin kappa J region (RBPJ) is a transcriptional repressor, but...
6.
Bassil R, Orent W, Olah M, Kurdi A, Frangieh M, Buttrick T, et al.
J Immunol
. 2014 Jun;
193(1):198-207.
PMID: 24879792
The transcriptional repressor B cell lymphoma 6 (BCL6) is required for the development of Th follicular cells, and it has been shown to suppress Th2 cell differentiation. We demonstrate that...
7.
Bassil R, Orent W, Elyaman W
Clin Dev Immunol
. 2013 Dec;
2013:570731.
PMID: 24324509
The Notch signaling pathway preservation across species hints to the indispensable role it plays during evolution. Over the last decade the science community has extensively studied the Notch signaling pathway,...
8.
Zhu B, Buttrick T, Bassil R, Zhu C, Olah M, Wu C, et al.
J Immunol
. 2013 Aug;
191(6):3139-51.
PMID: 23960232
Although activated inflammatory monocytes (IMCs) and inflammatory dendritic cells (IDCs) are potent T cell suppressors, nonactivated IMCs and IDCs promote T cell activation and Th1/Th17 cell differentiation. In this study,...
9.
Elyaman W, Bassil R, Bradshaw E, Orent W, Lahoud Y, Zhu B, et al.
Immunity
. 2012 Apr;
36(4):623-34.
PMID: 22503540
Interleukin 9 (IL-9) is a pleiotropic cytokine that can regulate autoimmune responses by enhancing regulatory CD4(+)FoxP3(+) T regulatory (Treg) cell survival and T helper 17 (Th17) cell proliferation. Here, we...